Incidence of child and adolescent mental disorders in children aged 0-17 with familial high risk for severe mental illness - A Danish register study.

Détails

ID Serval
serval:BIB_0F77702668D8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Incidence of child and adolescent mental disorders in children aged 0-17 with familial high risk for severe mental illness - A Danish register study.
Périodique
Schizophrenia research
Auteur(s)
Thorup AAE, Laursen T.M., Munk-Olsen T., Ranning A., Mortensen P.B., Plessen K.J., Nordentoft M.
ISSN
1573-2509 (Electronic)
ISSN-L
0920-9964
Statut éditorial
Publié
Date de publication
07/2018
Peer-reviewed
Oui
Volume
197
Pages
298-304
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Offspring of parents with severe mental illness (SMI: schizophrenia, bipolar disorder or major depressive disorder) have an increased risk of developing mental disorder themselves. In childhood they may have neurodevelopmental delays, cognitive deficits and social adversities. We aimed to investigate if these individuals are more at risk of being diagnosed with a mental disorder during childhood/adolescence in a national sample.
By linking Danish registers we established a cohort consisting of all persons born to parents with SMI with those born to parents without SMI serving as a reference group. Incidence rate ratios (IRRs) for offspring diagnosed with a mental disorder by parental mental disorder were calculated.
Offspring of parents with SMI showed increased IRR for all diagnoses of child and adolescent mental disorders compared to the reference group. Offspring of mothers with schizophrenia had IRR of 2.60 (CI: 2.50-2.70, N=2550) of having any diagnoses, for children of fathers with schizophrenia IRR was 2.06 (CI: 1.97-2.16, N=1901) and for offspring of two parents with schizophrenia IRR was 4.57 (CI: 3.94-5.31, N=175). For individuals with a mother with bipolar disorder the IRR was 2.29 (CI: 2.09-2.50, N=502), with a father 1.77 (CI: 1.74-1.87, N=320), whereas the IRR was 2.96 (CI: 2.63-3.34, N=264) if both parents had unipolar depression.
Offspring of parents with a SMI have a higher risk of being diagnosed with any child and adolescent mental disorder. The IRRs for all diagnoses during childhood were increased by a factor 2-4. Having two ill parents increased the IRR.
Mots-clé
Bipolar disorder, Child and adolescent psychiatry, Depression, Familial high risk, Register study, Schizophrenia
Pubmed
Web of science
Création de la notice
12/02/2019 9:59
Dernière modification de la notice
20/08/2019 13:36
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