Rapid diagnostic tests for non-malarial febrile illness in the tropics.

Détails

ID Serval
serval:BIB_0F56F0721C8F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Rapid diagnostic tests for non-malarial febrile illness in the tropics.
Périodique
Clinical Microbiology and Infection
Auteur(s)
Chappuis F., Alirol E., d'Acremont V., Bottieau E., Yansouni C.P.
ISSN
1469-0691 (Electronic)
ISSN-L
1198-743X
Statut éditorial
Publié
Date de publication
2013
Volume
19
Numéro
5
Pages
422-431
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish. PDF type: Review
Résumé
The recent roll-out of rapid diagnostic tests (RDTs) for malaria has highlighted the decreasing proportion of malaria-attributable illness in endemic areas. Unfortunately, once malaria is excluded, there are few accessible diagnostic tools to guide the management of severe febrile illnesses in low resource settings. This review summarizes the current state of RDT development for several key infections, including dengue fever, enteric fever, leptospirosis, brucellosis, visceral leishmaniasis and human African trypanosomiasis, and highlights many remaining gaps. Most RDTs for non-malarial tropical infections currently rely on the detection of host antibodies against a single infectious agent. The sensitivity and specificity of host-antibody detection tests are both inherently limited. Moreover, prolonged antibody responses to many infections preclude the use of most serological RDTs for monitoring response to treatment and/or for diagnosing relapse. Considering these limitations, there is a pressing need for sensitive pathogen-detection-based RDTs, as have been successfully developed for malaria and dengue. Ultimately, integration of RDTs into a validated syndromic approach to tropical fevers is urgently needed. Related research priorities are to define the evolving epidemiology of fever in the tropics, and to determine how combinations of RDTs could be best used to improve the management of severe and treatable infections requiring specific therapy.
Pubmed
Web of science
Open Access
Oui
Création de la notice
16/05/2013 16:47
Dernière modification de la notice
20/08/2019 12:36
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