Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_0F4E2D75CCBF
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes.
Périodique
Toxicology and applied pharmacology
Auteur(s)
Fritsche E., Grandjean P., Crofton K.M., Aschner M., Goldberg A., Heinonen T., Hessel EVS, Hogberg H.T., Bennekou S.H., Lein P.J., Leist M., Mundy W.R., Paparella M., Piersma A.H., Sachana M., Schmuck G., Solecki R., Terron A., Monnet-Tschudi F., Wilks M.F., Witters H., Zurich M.G., Bal-Price A.
ISSN
1096-0333 (Electronic)
ISSN-L
0041-008X
Statut éditorial
Publié
Date de publication
01/09/2018
Peer-reviewed
Oui
Volume
354
Pages
3-6
Langue
anglais
Notes
Publication types: Guideline ; Journal Article
Publication Status: ppublish
Résumé
This consensus statement voices the agreement of scientific stakeholders from regulatory agencies, academia and industry that a new framework needs adopting for assessment of chemicals with the potential to disrupt brain development. An increased prevalence of neurodevelopmental disorders in children has been observed that cannot solely be explained by genetics and recently pre- and postnatal exposure to environmental chemicals has been suspected as a causal factor. There is only very limited information on neurodevelopmental toxicity, leaving thousands of chemicals, that are present in the environment, with high uncertainty concerning their developmental neurotoxicity (DNT) potential. Closing this data gap with the current test guideline approach is not feasible, because the in vivo bioassays are far too resource-intensive concerning time, money and number of animals. A variety of in vitro methods are now available, that have the potential to close this data gap by permitting mode-of-action-based DNT testing employing human stem cells-derived neuronal/glial models. In vitro DNT data together with in silico approaches will in the future allow development of predictive models for DNT effects. The ultimate application goals of these new approach methods for DNT testing are their usage for different regulatory purposes.
Mots-clé
Age Factors, Animal Testing Alternatives/standards, Animals, Brain/drug effects, Brain/growth & development, Brain/pathology, Consensus, Diffusion of Innovation, Humans, Neurons/drug effects, Neurons/pathology, Neurotoxicity Syndromes/etiology, Neurotoxicity Syndromes/pathology, Neurotoxicity Syndromes/physiopathology, Policy Making, Reproducibility of Results, Risk Assessment, Stakeholder Participation, Toxicity Tests/methods, Toxicity Tests/standards, Toxicology/methods, Toxicology/standards, Developmental neurotoxicity, In vitro testing, Regulatory purposes
Pubmed
Web of science
Création de la notice
01/03/2018 21:55
Dernière modification de la notice
30/04/2021 7:08
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