Nitric oxide added to the sweep gas infusion reduces local clotting formation in adult blood oxygenators

Détails

ID Serval
serval:BIB_0F28A5ED7A8D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Nitric oxide added to the sweep gas infusion reduces local clotting formation in adult blood oxygenators
Périodique
ASAIO Journal
Auteur(s)
Tevaearai  H. T., Mueller  X. M., Tepic  S., Cotting  J., Boone  Y., Montavon  P. M., von Segesser  L. K.
ISSN
1058-2916
Statut éditorial
Publié
Date de publication
12/2000
Peer-reviewed
Oui
Volume
46
Numéro
6
Pages
719-22
Notes
In Vitro
Journal Article --- Old month value: Nov-Dec
Résumé
Nitric oxide (NO) is an inhibitor of platelet aggregation. We analyzed the effect of direct infusion of NO into adult blood oxygenators on local clot formation. Nonheparinized calves in a control group (n = 3) and NO group (n = 4) were connected to a jugulocarotid cardiopulmonary bypass (CPB; centrifugal pump) for 6 hours. The venous line and pumphead were heparin coated, whereas the oxygenator, the heat exchanger, and the arterial line were not. A total of 80 ppm of NO was mixed with the sweep gas infusion in the NO group. The pressure gradient through the oxygenator (delta<gd>P.Ox.) was monitored, and its evolution was compared between groups. Oxygenators membranes were analyzed and photographed, allowing for calculation of the percentage of surface area covered with clots by using a computer image analysis program. The delta<gd>P.Ox. reached a plateau of 193 +/- 26% of the basal value in the NO group after 120 minutes, whereas a similar plateau of 202 +/- 22% was reached after only 20 minutes in the control group (p < 0.05). The surface area of the oxygenator covered with clots was significantly reduced in the NO group (0.54 +/- 0.41%) compared with the control group (5.78 +/- 3.80%, p < 0.05). However, general coagulation parameters were not modified by local NO administration. The activated coagulation time remained stable between 110 and 150 seconds in both groups (p = not significant [ns]), and there were no differences in hematocrit, thrombin time, partial thromboplastin time, or fibrinogen between groups during the 6 hours of CPB. Thus, the mixed infusion of a continuous low dose of NO into adult oxygenators during prolonged CPB prevented local clot formation, whereas the general coagulation pattern remained unchanged.
Mots-clé
Animals Blood Coagulation/*drug effects Cardiopulmonary Bypass/adverse effects Cattle Gases Nitric Oxide/*administration & dosage *Oxygenators, Membrane/adverse effects Platelet Aggregation/drug effects Platelet Aggregation Inhibitors/*administration & dosage
Pubmed
Web of science
Création de la notice
14/02/2008 15:17
Dernière modification de la notice
20/08/2019 13:35
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