The risk of a second diagnostic window with 4th generation HIV assays: Two cases.

Détails

ID Serval
serval:BIB_0F25142D8849
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The risk of a second diagnostic window with 4th generation HIV assays: Two cases.
Périodique
Journal of Clinical Virology
Auteur(s)
Niederhauser C., Ströhle A., Stolz M., Müller F., Tinguely C.
ISSN
1873-5967 (Electronic)
ISSN-L
1386-6532
Statut éditorial
Publié
Date de publication
2009
Volume
45
Numéro
4
Pages
367-369
Langue
anglais
Notes
Publication types: Case Reports ; Comparative Study ; Evaluation Studies ; Journal Article Publication Status: ppublish
Résumé
BACKGROUND: Despite the improved sensitivity of the 4th generation combined antigen/antibody HIV assays, detection of HIV in the early phase of an infection may still be ineffective.
OBJECTIVES: Description of two cases that highlight the existence of the "second diagnostic window phase" observed with commonly used sensitive 4th generation HIV assays.
STUDY DESIGN: Samples were screened with different 4th generation HIV assays. HIV infection was confirmed with an HIV I/II antibody assay, a HIV-1 p24 antigen assay, the INNO-LIA HIV I/II Score Line immunoassay and HIV-1 PCR.
RESULTS: In both investigated cases, the limitations of the 4th generation HIV assays within the second diagnostic window were apparent.
CONCLUSIONS: The overall sensitivity of the commercial 4th generation HIV assays is currently higher than the 3rd generation HIV assays. Nevertheless, the rare occurrence of a second diagnostic window with 4th generation HIV assays strongly suggests that the following up testing algorithms need to be adjusted accordingly.
Mots-clé
Adult, HIV Antibodies/blood, HIV Core Protein p24/blood, HIV Infections/diagnosis, HIV-1/genetics, HIV-1/immunology, Humans, Immunoassay/methods, Male, Middle Aged, Molecular Diagnostic Techniques/methods, Polymerase Chain Reaction/methods, RNA, Viral/blood, Reagent Kits, Diagnostic, Sensitivity and Specificity, Young Adult
Pubmed
Web of science
Création de la notice
09/11/2014 15:51
Dernière modification de la notice
20/08/2019 12:35
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