Blood-brain barrier breakdown, neuroinflammation, and cognitive decline in older adults.

Détails

ID Serval
serval:BIB_0EFFC1931D8F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Blood-brain barrier breakdown, neuroinflammation, and cognitive decline in older adults.
Périodique
Alzheimer's & dementia
Auteur(s)
Bowman G.L., Dayon L., Kirkland R., Wojcik J., Peyratout G., Severin I.C., Henry H., Oikonomidi A., Migliavacca E., Bacher M., Popp J.
ISSN
1552-5279 (Electronic)
ISSN-L
1552-5260
Statut éditorial
Publié
Date de publication
12/2018
Peer-reviewed
Oui
Volume
14
Numéro
12
Pages
1640-1650
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Blood-brain barrier (BBB) breakdown is observed in older versus younger adults and in late-onset Alzheimer's disease versus age-matched controls, but its causes and consequences in aging are unclear. We tested the hypothesis that BBB breakdown is associated with cognitive decline and inflammation in nondemented elders.
Cerebrospinal fluid and serum inflammatory markers were measured using sandwich immunoassays in 120 subjects. Least Absolute Shrinkage and Selection Operator-logistic regression selected cerebrospinal fluid and serum signatures that best classified BBB impairment defined by the cerebrospinal fluid albumin index ≥9. Linear regression examined changes in Clinical Dementia Rating sum of boxes as a function of BBB integrity at baseline.
Mean age was 70 years, mean Mini–Mental State Examination was 27, and BBB impairment was recorded in 13.5%. BBB breakdown was associated with cognitive decline (P = .015). Cerebrospinal fluid intercellular adhesion molecule-1, vascular endothelial growth factor, interleukin-8, serum amyloid A, macrophage derived chemokine, and gender generated an area under the curve of 0.95 for BBB impairment, and serum IL-16, VEGF-D, IL-15, and other variables generated an AUC of 0.92 for BBB impairment.
BBB breakdown is associated with more rapid cognitive decline. Inflammatory mechanisms, including cell adhesion, neutrophil migration, lipid metabolism, and angiogenesis may be implicated.
Mots-clé
Aged, Apolipoprotein E4/genetics, Biomarkers/blood, Biomarkers/cerebrospinal fluid, Blood-Brain Barrier/metabolism, Cerebrovascular Disorders/blood, Cerebrovascular Disorders/cerebrospinal fluid, Cerebrovascular Disorders/immunology, Cognitive Dysfunction/blood, Cognitive Dysfunction/cerebrospinal fluid, Cognitive Dysfunction/immunology, Cohort Studies, Disease Progression, Female, Humans, Inflammation/blood, Inflammation/cerebrospinal fluid, Inflammation/immunology, Male, Neuropsychological Tests, Angiogenesis, Biomarkers, CSF, Chemokines, Cytokines, Elderly, HDL metabolism, IL-16, IL-8, MDC, Mild cognitive impairment, Neurovascular unit, Serum, Serum amyloid A, VEGF, sICAM-1
Pubmed
Web of science
Création de la notice
03/09/2018 10:53
Dernière modification de la notice
11/10/2019 6:09
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