Extraintestinal manifestations of Crohn's disease.

Détails

ID Serval
serval:BIB_0EF09B21634C
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Extraintestinal manifestations of Crohn's disease.
Périodique
Digestion
Auteur(s)
Juillerat Pascal, Mottet Christian, Pittet Valérie, Froehlich Florian, Felley Christian, Gonvers Jean-Jacques, Vader John-Paul, Michetti Pierre
ISSN
1421-9867[electronic]
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
76
Numéro
2
Pages
141-148
Langue
anglais
Résumé
In each case of extraintestinal manifestations of Crohn's disease, active disease, if present, should be treated to induce remission, which may positively influence the course of most concomitant extraintestinal manifestations. For some extraintestinal manifestations, however, a specific treatment should be introduced. This latter part of disease management will be discussed in this chapter, in particular for pyoderma gangrenosum, uveitis, spondylarthropathy - axial arthropathy - and primary sclerosing cholangitis, which have also been described in quiescent Crohn's disease. Few new drugs for the treatment of extraintestinal manifestations of Crohn's disease have been developed in the past and only the role of infliximab has increased in Crohn's disease-related extraintestinal manifestations. Drugs specifically aimed at this treatment, stemming from a few randomized controlled studies or case series, are sulfasalazine, 5-ASA, corticosteroids, azathioprine or 6-mercaptopurine, methotrexate, infliximab, adalimumab, etanercept and cyclosporine or tacrolimus. Unfortunately, because of the paucity of data in this field, the best evidence presented and discussed in this article for the treatment of these extraintestinal manifestations is extrapolated from patients that for the most part did not suffer from Crohn's disease.
Mots-clé
Cholangitis, Sclerosing/etiology, Cholangitis, Sclerosing/therapy, Crohn Disease/complications, Disease Progression, Humans, Pyoderma Gangrenosum/etiology, Pyoderma Gangrenosum/therapy, Spondylitis, Ankylosing/etiology, Spondylitis, Ankylosing/therapy, Uveitis/etiology, Uveitis/therapy
Pubmed
Web of science
Création de la notice
29/02/2008 17:30
Dernière modification de la notice
20/08/2019 13:35
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