Hepatic histology in obese patients undergoing bariatric surgery

Détails

ID Serval
serval:BIB_0EE440B1A76D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Hepatic histology in obese patients undergoing bariatric surgery
Périodique
Journal of Hepatology
Auteur(s)
Machado M., Marques-Vidal P., Cortez-Pinto H.
ISSN
0168-8278 (Print)
ISSN-L
0168-8278
Statut éditorial
Publié
Date de publication
2006
Volume
45
Numéro
4
Pages
600-606
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
BACKGROUND/AIMS: Obesity is one of the most important clinical associations with non-alcoholic steatohepatitis (NASH). Our aim was to assess the prevalence of non-alcoholic fatty liver disease (NAFLD)/NASH in morbidly obese patients and the risk factors to more aggressive liver disease in this population.
METHODS: Review of available studies on prevalence of NAFLD/NASH in severely obese patients submitted to bariatric surgery.
RESULTS: Twelve observational and transversal studies were included, with consecutive recruitment, and prospective evaluation of data, summing 1620 patients with severe obesity. Prevalence of steatosis and NASH was 91% (range: 85-98%) and 37% (24-98%), respectively, with unexpected cirrhosis in 1.7% (1-7%). NASH was not related with age or body mass index, but there was an association between male sex and NASH/hepatic fibrosis. Diabetes mellitus and insulin resistance were the conditions most frequently associated with NASH, and hypertension with advanced hepatic fibrosis.
CONCLUSIONS: There is a very high prevalence of NAFLD in asymptomatic morbidly obese patients, more than one-third presenting histological criteria for NASH. This review underscores the large variations in prevalence of NASH between studies, calling for the need for a better agreement in the use of the histological criteria.
Mots-clé
Dyslipidemias/epidemiology, Fatty Liver/epidemiology, Fatty Liver/pathology, Hypertension/epidemiology, Liver/pathology, Liver Cirrhosis/epidemiology, Liver Cirrhosis/pathology, Obesity, Morbid/epidemiology, Obesity, Morbid/pathology, Obesity, Morbid/surgery, Transaminases/blood
Pubmed
Web of science
Création de la notice
01/12/2016 15:01
Dernière modification de la notice
20/08/2019 12:35
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