Bioengineering of Human Fetal Tissues For Clinical Use

Détails

ID Serval
serval:BIB_0ED4915CE834
Type
Partie de livre
Sous-type
Chapitre: chapitre ou section
Collection
Publications
Institution
Titre
Bioengineering of Human Fetal Tissues For Clinical Use
Titre du livre
Bioengineering: Principles, Methodologies and Applications
Auteur(s)
Applegate L.A., Hirt-Burri N., Scaletta C., Bauren J.-F., Pioletti D.P.
Editeur
Nova Science Publisher's
Lieu d'édition
Hauppauge, NY
ISBN
978-1-60741-762-0
Statut éditorial
Publié
Date de publication
2009
Editeur scientifique
Garcia Audric, Durand Ciel
Numéro de chapitre
4
Pages
133-152
Langue
anglais
Résumé
Cultured primary fetal cells from one organ donation could possibly meet the exigent
and stringent technical aspects for development of therapeutic products. These cell types
have fewer technological limitations for cellular proliferation capacity (simple culture
conditions) and maintenance of differentiated phenotype, and they also have low
probability for transmission of communicable diseases. Master and Working Cell Banks
(MCB, WCB) can be obtained from one fetal organ donation, permitting multiple tissues
(skin, bone, cartilage, muscle and intervertebral disc) to be processed in short periods of
time with identical methods to assure a stringent tracing of the processes for the
production of standardized therapeutic agents. Clinical use of biologics from embryo and
fetal tissues is relatively new and current legislation and ethics have some differences
between countries to date. In addition, specific cell delivery systems for each tissue type
can be adapted to the clinical application. Since it is the intention that banked primary
fetal cells enhance the prospective treatment of hundreds of thousands of patients with
only one organ donation, it is imperative to show consistency, traceability and safety of
the processes including donor tissue selection, cell banking, cell testing and growth of
cells in out-scaling for the preparation of bio-engineered products for clinical application.
Création de la notice
05/02/2010 14:19
Dernière modification de la notice
20/08/2019 12:35
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