TSLP-activated dendritic cells induce human T follicular helper cell differentiation through OX40-ligand.

Détails

Ressource 1Télécharger: 28428203_BIB_0EAFECFB56C6.pdf (2583.80 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_0EAFECFB56C6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
TSLP-activated dendritic cells induce human T follicular helper cell differentiation through OX40-ligand.
Périodique
The Journal of experimental medicine
Auteur(s)
Pattarini L., Trichot C., Bogiatzi S., Grandclaudon M., Meller S., Keuylian Z., Durand M., Volpe E., Madonna S., Cavani A., Chiricozzi A., Romanelli M., Hori T., Hovnanian A., Homey B., Soumelis V.
ISSN
1540-9538 (Electronic)
ISSN-L
0022-1007
Statut éditorial
Publié
Date de publication
01/05/2017
Peer-reviewed
Oui
Volume
214
Numéro
5
Pages
1529-1546
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
T follicular helper cells (Tfh) are important regulators of humoral responses. Human Tfh polarization pathways have been thus far associated with Th1 and Th17 polarization pathways. How human Tfh cells differentiate in Th2-skewed environments is unknown. We show that thymic stromal lymphopoietin (TSLP)-activated dendritic cells (DCs) promote human Tfh differentiation from naive CD4 T cells. We identified a novel population, distinct from Th2 cells, expressing IL-21 and TNF, suggestive of inflammatory cells. TSLP-induced T cells expressed CXCR5, CXCL13, ICOS, PD1, BCL6, BTLA, and SAP, among other Tfh markers. Functionally, TSLP-DC-polarized T cells induced IgE secretion by memory B cells, and this depended on IL-4Rα. TSLP-activated DCs stimulated circulating memory Tfh cells to produce IL-21 and CXCL13. Mechanistically, TSLP-induced Tfh differentiation depended on OX40-ligand, but not on ICOS-ligand. Our results delineate a pathway of human Tfh differentiation in Th2 environments.

Pubmed
Open Access
Oui
Création de la notice
29/04/2017 17:10
Dernière modification de la notice
20/08/2019 13:35
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