Early survival prediction after intra-arterial therapies: a 3D quantitative MRI assessment of tumour response after TACE or radioembolization of colorectal cancer metastases to the liver.

Détails

Ressource 1Télécharger: BIB_0E90E64DD5C3.P001.pdf (1622.42 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_0E90E64DD5C3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Early survival prediction after intra-arterial therapies: a 3D quantitative MRI assessment of tumour response after TACE or radioembolization of colorectal cancer metastases to the liver.
Périodique
European Radiology
Auteur(s)
Chapiro J., Duran R., Lin M., Schernthaner R., Lesage D., Wang Z., Savic L.J., Geschwind J.F.
ISSN
1432-1084 (Electronic)
ISSN-L
0938-7994
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
25
Numéro
7
Pages
1993-2003
Langue
anglais
Notes
Publication types: Evaluation Studies ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
OBJECTIVES: This study evaluated the predictive role of 1D, 2D and 3D quantitative, enhancement-based MRI regarding overall survival (OS) in patients with colorectal liver metastases (CLM) following intra-arterial therapies (IAT).
METHODS: This retrospective analysis included 29 patients who underwent transarterial chemoembolization (TACE) or radioembolization and received MRI within 6 weeks after therapy. Tumour response was assessed using 1D and 2D criteria (such as European Association for the Study of the Liver guidelines [EASL] and modified Response Evaluation Criteria in Solid Tumors [mRECIST]). In addition, a segmentation-based 3D quantification of overall (volumetric [v] RECIST) and enhancing lesion volume (quantitative [q] EASL) was performed on portal venous phase MRI. Accordingly, patients were classified as responders (R) and non-responders (NR). Survival was evaluated using Kaplan-Meier analysis and compared using Cox proportional hazard ratios (HR).
RESULTS: Only enhancement-based criteria identified patients as responders. EASL and mRECIST did not predict patient survival (P = 0.27 and P = 0.44, respectively). Using uni- and multivariate analysis, qEASL was identified as the sole predictor of patient survival (9.9 months for R, 6.9 months for NR; P = 0.038; HR 0.4).
CONCLUSION: The ability of qEASL to predict survival early after IAT provides evidence for potential advantages of 3D quantitative tumour analysis.
KEY POINTS: ? Volumetric assessment of colorectal liver metastases after intra-arterial therapy is feasible. ? Early 3D quantitative tumour analysis after intra-arterial therapy may predict patient survival. ? Volumetric tumour response assessment shows advantages over 1D and 2D techniques. ? Enhancement-based MR response assessment is preferable to size-based measurements.
Mots-clé
Adult, Aged, Aged, 80 and over, Chemoembolization, Therapeutic/methods, Chemoembolization, Therapeutic/mortality, Colorectal Neoplasms, Embolization, Therapeutic/methods, Embolization, Therapeutic/mortality, Female, Humans, Kaplan-Meier Estimate, Liver Neoplasms/mortality, Liver Neoplasms/secondary, Magnetic Resonance Imaging/methods, Magnetic Resonance Imaging/mortality, Male, Middle Aged, Retrospective Studies, Treatment Outcome, Tumor Burden
Pubmed
Création de la notice
03/09/2015 10:06
Dernière modification de la notice
20/08/2019 12:35
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