A role for clock genes in sleep homeostasis.

Détails

ID Serval
serval:BIB_0E537B7CDA17
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
A role for clock genes in sleep homeostasis.
Périodique
Current Opinion in Neurobiology
Auteur(s)
Franken P.
ISSN
1873-6882 (Electronic)
ISSN-L
0959-4388
Statut éditorial
Publié
Date de publication
2013
Volume
23
Numéro
5
Pages
864-872
Langue
anglais
Résumé
The timing and quality of both sleep and wakefulness are thought to be regulated by the interaction of two processes. One of these two processes keeps track of the prior sleep-wake history and controls the homeostatic need for sleep while the other sets the time-of-day that sleep preferably occurs. The molecular pathways underlying the latter, circadian process have been studied in detail and their key role in physiological time-keeping has been well established. Analyses of sleep in mice and flies lacking core circadian clock gene proteins have demonstrated, however, that besides disrupting circadian rhythms, also sleep homeostatic processes were affected. Subsequent studies revealed that sleep loss alters both the mRNA levels and the specific DNA-binding of the key circadian transcriptional regulators to their target sequences in the mouse brain. The fact that sleep loss impinges on the very core of the molecular circadian circuitry might explain why both inadequate sleep and disrupted circadian rhythms can similarly lead to metabolic pathology. The evidence for a role for clock genes in sleep homeostasis will be reviewed here.
Pubmed
Web of science
Création de la notice
06/02/2014 15:27
Dernière modification de la notice
20/08/2019 13:35
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