Surgical Site Infections, Risk Factors, and Outcomes After Liver Transplant.
Détails
ID Serval
serval:BIB_0E3CD6D499CE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Surgical Site Infections, Risk Factors, and Outcomes After Liver Transplant.
Périodique
JAMA network open
Collaborateur⸱rice⸱s
Swiss Transplant Cohort Study
Contributeur⸱rice⸱s
Amico P., Bachofner A., Banz V., Beckmann S., Beldi G., Berger C., Berishvili E., Berzigotti A., Binet I., Bochud P.Y., Branca S., Cairoli A., Catana E., Chalandon Y., De Geest S., De Seigneux S., Dreifuss J.L., Duchosal M., Fehr T., Ferrari-Lacraz S., Frossard J., Golshayan D., Goossens N., Haidar F., Heim D., Hess C., Hillinger S., Hirsch H.H., Hirt P., Hoessly L., Hofbauer G., Huynh-Do U., Khanna N., Koller M., Kremer A., Krueger T., Kuhn C., Laesser B., Lamoth F., Lehmann R., Leichtle A., Manuel O., Marti H.P., Martinelli M., McLin V., Mellac K., Mercay A., Mettler K., Müller N., Müller-Arndt U., Nägeli M., Oldani G., Pascual M., Pazeller R., Posfay-Barbe K., Reineke D., Rick J., Rossi S., Rössler F., Rothlin S., Ruschitzka F., Schachtner T., Schaub S., Schneidawind D., Schuurmans M., Schwab S., Sengstag T., Simonetta F., Steiger J., Stirniman G., Stürzinger U., Van Delden C., Venetz J.P., Villard J., Vionnet J., Wehmeier C., Wick M., Wilhelm M., Yerly P.
ISSN
2574-3805 (Electronic)
ISSN-L
2574-3805
Statut éditorial
Publié
Date de publication
03/03/2025
Peer-reviewed
Oui
Volume
8
Numéro
3
Pages
e251333
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study
Publication Status: epublish
Publication Status: epublish
Résumé
Surgical site infections (SSIs) are one of the most common health care-associated infections. Surgical site infections can have harmful effects in liver transplant (LT) recipients.
To assess the incidence of SSI after LT and identify risk factors associated with SSIs and whether SSIs are associated with death and graft loss.
A multicenter cohort study encompassing data on LT performed at all Swiss transplant centers between May 1, 2008, and September 30, 2020, was conducted. Data analyses were performed in 2023.
Liver transplant.
Frequency of SSIs within 90 days after transplant, risk factors associated with SSIs, and association of SSIs with 1-year death or graft loss. Surgical site infections were defined according to Centers for Disease Control and Prevention criteria with SSIs occurring within 90 days after LT. For association with posttransplant outcomes, 1-year follow-up data were analyzed.
Among 1333 LT recipients in the Swiss Transplant Cohort Study, 1158 adults were included in analyses. Median age was 57.2 (IQR, 49.3-62.8) years and 792 were men (68.4%). Seventy patients (6.0%) had an SSI. Most SSIs were deep incisional (9 [12.8%]) or organ-space infections (54 [77.1%]). In most SSIs (56 [80.0%]), bacteria were detected, most frequently Enterococcus spp (36 of 75 [48.0%]) and Escherichia coli (12 of 75 [16.0%]). In multivariable analysis, prior liver transplant (odds ratio [OR] 4.01; 95% CI, 1.44-11.18; P = .008) and living liver donation (OR, 4.08; 95% CI, 1.37-12.16; P = .01) were independent risk factors associated with SSIs. Surgical site infections were independently associated with graft loss and/or death (hazard ratio [HR], 3.24; 95% CI, 1.82-5.79; P < .001); this association was observed in separate analyses on graft loss (HR, 2.97; 95% CI, 1.32-6.68; P = .02) and death (HR, 3.25; 95% CI, 1.44-7.35; P = .01).
The findings of this study suggest that prior liver transplant and living liver donation are independent risk factors associated with SSIs and that SSIs are independently associated with graft loss and/or death, highlighting the relevance of this health care-associated infection.
To assess the incidence of SSI after LT and identify risk factors associated with SSIs and whether SSIs are associated with death and graft loss.
A multicenter cohort study encompassing data on LT performed at all Swiss transplant centers between May 1, 2008, and September 30, 2020, was conducted. Data analyses were performed in 2023.
Liver transplant.
Frequency of SSIs within 90 days after transplant, risk factors associated with SSIs, and association of SSIs with 1-year death or graft loss. Surgical site infections were defined according to Centers for Disease Control and Prevention criteria with SSIs occurring within 90 days after LT. For association with posttransplant outcomes, 1-year follow-up data were analyzed.
Among 1333 LT recipients in the Swiss Transplant Cohort Study, 1158 adults were included in analyses. Median age was 57.2 (IQR, 49.3-62.8) years and 792 were men (68.4%). Seventy patients (6.0%) had an SSI. Most SSIs were deep incisional (9 [12.8%]) or organ-space infections (54 [77.1%]). In most SSIs (56 [80.0%]), bacteria were detected, most frequently Enterococcus spp (36 of 75 [48.0%]) and Escherichia coli (12 of 75 [16.0%]). In multivariable analysis, prior liver transplant (odds ratio [OR] 4.01; 95% CI, 1.44-11.18; P = .008) and living liver donation (OR, 4.08; 95% CI, 1.37-12.16; P = .01) were independent risk factors associated with SSIs. Surgical site infections were independently associated with graft loss and/or death (hazard ratio [HR], 3.24; 95% CI, 1.82-5.79; P < .001); this association was observed in separate analyses on graft loss (HR, 2.97; 95% CI, 1.32-6.68; P = .02) and death (HR, 3.25; 95% CI, 1.44-7.35; P = .01).
The findings of this study suggest that prior liver transplant and living liver donation are independent risk factors associated with SSIs and that SSIs are independently associated with graft loss and/or death, highlighting the relevance of this health care-associated infection.
Mots-clé
Humans, Liver Transplantation/adverse effects, Liver Transplantation/mortality, Male, Female, Middle Aged, Risk Factors, Surgical Wound Infection/epidemiology, Surgical Wound Infection/mortality, Surgical Wound Infection/etiology, Switzerland/epidemiology, Incidence, Cohort Studies, Adult
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/03/2025 15:10
Dernière modification de la notice
24/05/2025 7:11
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