Carbohydrate metabolism and de novo lipogenesis in human obesity.

Détails

ID Serval
serval:BIB_0E3A386C2FBF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Carbohydrate metabolism and de novo lipogenesis in human obesity.
Périodique
American Journal of Clinical Nutrition
Auteur(s)
Acheson K.J., Schutz Y., Bessard T., Flatt J.P., Jéquier E.
ISSN
0002-9165 (Print)
ISSN-L
0002-9165
Statut éditorial
Publié
Date de publication
1987
Volume
45
Numéro
1
Pages
78-85
Langue
anglais
Résumé
Respiratory exchange was measured during 14 consecutive hours in six lean and six obese individuals after ingestion of 500 g of dextrin maltose to investigate and compare their capacity for net de novo lipogenesis. After ingestion of the carbohydrate load, metabolic rates rose similarly in both groups but fell earlier and more rapidly in the obese. RQs also rose rapidly and remained in the range of 0.95 to 1.00 for approximately 8 h in both groups. During this time, RQ exceeded 1.00 for only short periods of time with the result that 4 +/- 1 g and 5 +/- 3 g (NS) of fat were synthesized via de novo lipogenesis in excess of concomitant fat oxidation in the lean and obese subjects, respectively. Results demonstrate that net de novo lipid synthesis from an unusually large carbohydrate load is not greater in obese than in lean individuals.
Mots-clé
Adult, Dextrins/metabolism, Dietary Carbohydrates/metabolism, Energy Metabolism, Female, Humans, Lipids/biosynthesis, Male, Maltose/metabolism, Obesity/metabolism, Oxidation-Reduction, Respiration
Pubmed
Web of science
Création de la notice
21/01/2008 14:07
Dernière modification de la notice
20/08/2019 13:35
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