Molecular epidemiology of predominant clones and sporadic strains of methicillin resistant Staphylococcus aureus in Switzerland and comparison with European epidemic clones.

Détails

ID Serval
serval:BIB_0E26C40A9357
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Molecular epidemiology of predominant clones and sporadic strains of methicillin resistant Staphylococcus aureus in Switzerland and comparison with European epidemic clones.
Périodique
Clinical Microbiology and Infection
Auteur(s)
Blanc D.S., Pittet D., Ruef C., Widmer A.F., Mühlemann K., Petignat C., Harbarth S., Auckenthaler R., Bille J., Frei R., Zbinden R., Moreillon P., Sudre P., Francioli P.
ISSN
1198-743X (Print)
ISSN-L
1198-743X
Statut éditorial
Publié
Date de publication
2002
Peer-reviewed
Oui
Volume
8
Numéro
7
Pages
419-426
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
OBJECTIVE: To assess the molecular epidemiology and risk factors of predominant clones and sporadic strains of methicillin-resistant Staphylococcus aureus (MRSA) in Swiss hospitals and to compare them with European strains of epidemic clones.
MATERIAL AND METHODS: One-year national survey of MRSA cases. Analysis of epidemiological and molecular typing data (PFGE) of MRSA strains.
RESULTS: In 1997, 385 cases of MRSA were recorded in the five Swiss university hospitals and in 47 community hospitals. Half of the cases were found in Geneva hospitals where MRSA was already known to be endemic. Molecular typing of 288 isolates (one per case) showed that 186 (65%) belong to four predominant clones, three of which were mostly present in Geneva hospitals. In contrast, the fourth clone (85 cases) was found in 23 hospitals (in one to 16 cases per hospital). The remaining 35% of the strains were clustered into 62 pulsed field gel electrophoresis types. They accounted for one to five patients per hospital and were defined as sporadic. Multivariate analysis revealed no independent risk factors for harboring a predominant versus a sporadic strain, except that transfer from a foreign hospital increases the risk of harboring a sporadic strain (OR, 42; 95% CI, 5-360).
CONCLUSION: While cases with predominant clones were due to the local spread of these clones, most sporadic cases appear to be due to the continuous introduction of new strains into the country. With the exception of a transfer from a hospital outside Switzerland, no difference in the clinical or epidemiological characteristics was observed between patients harboring a predominant clone and those with a sporadic strain.
Mots-clé
Anti-Bacterial Agents/pharmacology, Electrophoresis, Gel, Pulsed-Field, Europe/epidemiology, Female, Hospitals, Humans, Male, Methicillin Resistance, Nursing Homes, Phylogeny, Risk Factors, Staphylococcal Infections/drug therapy, Staphylococcal Infections/epidemiology, Staphylococcus aureus/classification, Staphylococcus aureus/drug effects, Switzerland/epidemiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 13:58
Dernière modification de la notice
20/08/2019 12:35
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