Fully-automated systems and the need for global approaches should exhort clinical labs to reinvent routine MS analysis?

Détails

ID Serval
serval:BIB_0E23CCB1FA7F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Fully-automated systems and the need for global approaches should exhort clinical labs to reinvent routine MS analysis?
Périodique
Bioanalysis
Auteur(s)
Rochat B.
ISSN
1757-6199 (Electronic)
ISSN-L
1757-6180
Statut éditorial
Publié
Date de publication
01/07/2018
Peer-reviewed
Oui
Volume
10
Numéro
14
Pages
1129-1141
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Today, many LC-high-resolution MS instruments have become affordable, easy-to-use, sensitive and quantitative. Meanwhile, there is an increased need for more comprehensive approaches. However, omics analyses are still restricted to specialists whereas, in hospitals, routine analyses are targeted and quantitative and represent the main and heavy tasks. But the availability of fully automated LC-MS instruments that can handle independently from sample extraction to result reporting, as well as the increasing biomedical interest for global approaches, clinical analytical workflow should be reorganized. Bioanalysts are now in the position to develop/implement clinical metabolomics or proteomics as routine analyses. In this article, this coming evolution and the reasons to implement global/omics determinations as routine analysis, is described.
Mots-clé
Automation/economics, Chromatography, Liquid/economics, Clinical Laboratory Techniques/economics, Humans, Mass Spectrometry/economics, Metabolomics, Methadone/blood, Proteomics, Testosterone/blood, LC–MS, LDT, automation, clinical metabolomics, clinical proteomics, high-resolution mass spectrometry (HRMS), laboratory developed tests
Pubmed
Web of science
Création de la notice
18/07/2018 14:30
Dernière modification de la notice
21/08/2019 5:33
Données d'usage