Prospective validation of the Pulmonary Embolism Severity Index. A clinical prognostic model for pulmonary embolism

Détails

ID Serval
serval:BIB_0E06BB79D835
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Prospective validation of the Pulmonary Embolism Severity Index. A clinical prognostic model for pulmonary embolism
Périodique
Thrombosis and Haemostasis
Auteur(s)
Donzé J., Le Gal G., Fine M.J., Roy P.M., Sanchez O., Verschuren F., Cornuz J., Meyer G., Perrier A., Righini M., Aujesky D.
ISSN
0340-6245
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
100
Numéro
5
Pages
943-948
Langue
anglais
Résumé
Practice guidelines recommend outpatient care for selected patients with non-massive pulmonary embolism (PE), but fail to specify how these low-risk patients should be identified. Using data from U.S. patients, we previously derived the Pulmonary Embolism Severity Index (PESI), a prediction rule that risk stratifies patients with PE. We sought to validate the PESI in a European patient cohort. We prospectively validated the PESI in patients with PE diagnosed at six emergency departments in three European countries. We used baseline data for the rule's 11 prognostic variables to stratify patients into five risk classes (I-V) of increasing probability of mortality. The outcome was overall mortality at 90 days after presentation. To assess the accuracy of the PESI to predict mortality, we estimated the sensitivity, specificity, and predictive values for low- (risk classes I/II) versus higher-risk patients (risk classes III-V), and the discriminatory power using the area under the receiver operating characteristic (ROC) curve. Among 357 patients with PE, overall mortality was 5.9%, ranging from 0% in class I to 17.9% in class V. The 186 (52%) low-risk patients had an overall mortality of 1.1% (95% confidence interval [CI]: 0.1-3.8%) compared to 11.1% (95% CI: 6.8-16.8%) in the 171 (48%) higher-risk patients. The PESI had a high sensitivity (91%, 95% CI: 71-97%) and a negative predictive value (99%, 95% CI: 96-100%) for predicting mortality. The area under the ROC curve was 0.78 (95% CI: 0.70-0.86). The PESI reliably identifies patients with PE who are at low risk of death and who are potential candidates for outpatient care. The PESI may help physicians make more rational decisions about hospitalization for patients with PE.
Mots-clé
Aged, Aged, 80 and over, Ambulatory Care, Europe, Female, Hospitalization, Humans, Male, Middle Aged, Predictive Value of Tests, Prognosis, Prospective Studies, Pulmonary Embolism, ROC Curve, Reproducibility of Results, Risk Assessment, Risk Factors, Sensitivity and Specificity, Severity of Illness Index, Time Factors
Pubmed
Web of science
Création de la notice
22/01/2009 10:22
Dernière modification de la notice
20/08/2019 12:35
Données d'usage