Differential control of transcription by homologous homeodomain coregulators.

Détails

ID Serval
serval:BIB_0DFBAFD5393D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Differential control of transcription by homologous homeodomain coregulators.
Périodique
Molecular and Cellular Biology
Auteur(s)
Huang C.C., Herr W.
ISSN
0270-7306[print], 0270-7306[linking]
Statut éditorial
Publié
Date de publication
06/1996
Volume
16
Numéro
6
Pages
2967-2976
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Résumé
The human herpes simplex virus type 1 (HSV-1) transactivator VP16 and its homolog from bovine herpes-virus 1 (BHV-1) can each recruit the human homeodomain protein Oct-1 into a transcriptional regulatory complex. Here, we show that these two Oct-1 coregulators possess similar, if not identical, homeodomain recognition properties but possess different virus-specific cis-regulatory specificities: the HSV-1 VP-16 protein activates transcription from the HSV-1 VP16 response element, and the BHV-1 VP16 protein activates transcription from the BHV-1 VP16 response element. A distinct 3-bp segment, the D segment, lying 3' of the canonical TAATGARAT motif (where R is a purine) in the VP16 response element is responsible for the differential cis element recognition and transcriptional activation by these two homeodomain coregulators. These results demonstrate how a single homeodomain protein can direct differential transcriptional regulation by selective association with homologous homeodomain coregulators.
Mots-clé
Animals, Base Sequence, Binding Sites/genetics, Cattle, Consensus Sequence, DNA, Viral/genetics, DNA, Viral/metabolism, DNA-Binding Proteins/genetics, DNA-Binding Proteins/metabolism, Genes, Regulator, Genes, Viral, Hela Cells, Herpesvirus 1, Bovine/genetics, Herpesvirus 1, Human/genetics, Homeodomain Proteins/genetics, Homeodomain Proteins/metabolism, Host Cell Factor C1, Humans, Molecular Sequence Data, Octamer Transcription Factor-1, Octamer Transcription Factor-2, Trans-Activators/genetics, Trans-Activators/metabolism, Transcription Factors/genetics, Transcription Factors/metabolism, Transcription, Genetic
Pubmed
Web of science
Création de la notice
24/01/2008 16:36
Dernière modification de la notice
20/08/2019 13:35
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