Mediators of Inflammation in Asthma: A Forensic Perspective.

Détails

ID Serval
serval:BIB_0DB52569BCB1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Mediators of Inflammation in Asthma: A Forensic Perspective.
Périodique
The American journal of forensic medicine and pathology
Auteur(s)
Schirripa M.L., Scarpelli M.P., Palmiere C.
ISSN
1533-404X (Electronic)
ISSN-L
0195-7910
Statut éditorial
Publié
Date de publication
06/2017
Peer-reviewed
Oui
Volume
38
Numéro
2
Pages
153-158
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
In the clinical setting, the role of systemic inflammation in patients with asthma has attracted increased attention, and some authors showed that increased IL-6 and high-sensitivity C-reactive protein characterized a group of asthmatic patients. In the realm of forensic pathology, a postmortem diagnosis of asthmatic death can be extremely challenging. The aim of this study was to determine the postmortem serum levels of C-reactive protein, IL-6, and tumor necrosis factor α in a series of severe acute bronchial asthma deaths that underwent medicolegal investigations. A total of 35 autopsy cases were retrospectively selected and included deaths in asthmatic subjects (related and unrelated to severe acute bronchial asthma, in situations characterized or not by systemic inflammation) as well as deaths in nonasthmatic individuals (in situations characterized or not by systemic inflammation). Our findings suggest that IL-6 is selectively increased in the systemic circulation of individuals with asthma, irrespective of whether the cause of death depends on a fatal asthma attack, compared with other biomarkers. Accordingly, postmortem serum IL-6 values in cases of death during severe acute bronchial asthma can be measured and considered of diagnostic relevance to estimate the magnitude of the systemic inflammation responses characterizing the disease.

Pubmed
Web of science
Création de la notice
09/03/2017 15:15
Dernière modification de la notice
20/08/2019 12:34
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