Anti-Yo antibody associated with occult fallopian tube carcinoma.

Détails

ID Serval
serval:BIB_0D9D1AE77B60
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Anti-Yo antibody associated with occult fallopian tube carcinoma.
Périodique
International journal of gynecological pathology
Auteur(s)
Selby K.J., Warner J., Klempner S., Konstantinopoulos P.A., Hecht J.L.
ISSN
1538-7151 (Electronic)
ISSN-L
0277-1691
Statut éditorial
Publié
Date de publication
11/2011
Peer-reviewed
Oui
Volume
30
Numéro
6
Pages
536-538
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Résumé
This is the case report of a 61-year-old woman who presented with progressive diplopia and ataxia. Her cerebrospinal fluid revealed high titers of anti-Yo (PCA-1) antibody and a magnetic resonance imaging with contrast showed cerebellar degeneration. Extensive imaging workup was negative for malignancy and she was otherwise asymptomatic. Given the association between anti-Yo antibodies and gynecologic malignancies, she underwent a bilateral salpingo-oophorectomy and cancer staging. Extensive section of the fimbriated end of the fallopian tube revealed a stage 1, microscopic serous adenocarcinoma. After surgery, her anti-YO titers fell and plans were made for adjuvant chemotherapy. Her neurologic symptoms are not expected to substantially improve, illustrating the urgent need for early surgical investigation in cases of paraneoplastic syndrome, even in the absence of imaging evidence of a lesion.
Mots-clé
Adenocarcinoma/immunology, Adenocarcinoma/pathology, Ataxia/etiology, Autoantibodies/cerebrospinal fluid, Autoantibodies/immunology, Cystadenocarcinoma, Serous/immunology, Cystadenocarcinoma, Serous/pathology, Diplopia/etiology, Fallopian Tube Neoplasms/immunology, Fallopian Tube Neoplasms/pathology, Female, Humans, Middle Aged, Nerve Tissue Proteins/immunology, Paraneoplastic Cerebellar Degeneration/etiology, Paraneoplastic Cerebellar Degeneration/immunology
Pubmed
Web of science
Création de la notice
15/06/2020 13:53
Dernière modification de la notice
23/06/2020 15:13
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