Targeted treatments for metastatic esophageal squamous cell cancer.

Détails

ID Serval
serval:BIB_0D8DC0748A82
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Targeted treatments for metastatic esophageal squamous cell cancer.
Périodique
World Journal of Gastrointestinal Oncology
Auteur(s)
Digklia A., Voutsadakis I.A.
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
5
Numéro
5
Pages
88-96
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Squamous cell carcinoma, one of the two major sub-types of esophageal carcinomas, constitutes the great majority of tumors in the upper and middle third of the organ. Declining in incidence in western countries, it continues to be a significant public health problem in the far east. Targeted treatments are novel therapies introduced in the clinical therapeutic armamentarium of oncology in the last 10-15 years. They represent a rational way of treating various cancers based on their molecular lesions. Although no such agent has been approved so far for the treatment of esophageal squamous cell carcinomas (ESCC), several are in clinical trials and several others have displayed pre-clinical activity that would justify the efforts and risks of pursuing their clinical development in this disease. This paper discusses some of these targeted agents in more advanced development in metastatic ESCC, as well as some promising drugs with pre-clinical or initial clinical data in the disease.
Pubmed
Open Access
Oui
Création de la notice
18/10/2016 14:13
Dernière modification de la notice
05/10/2020 6:26
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