Causal associations between risk factors and common diseases inferred from GWAS summary data.

Détails

Ressource 1Télécharger: 29335400_BIB_0D6E11812AAF.pdf (972.07 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_0D6E11812AAF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Causal associations between risk factors and common diseases inferred from GWAS summary data.
Périodique
Nature communications
Auteur⸱e⸱s
Zhu Z., Zheng Z., Zhang F., Wu Y., Trzaskowski M., Maier R., Robinson M.R., McGrath J.J., Visscher P.M., Wray N.R., Yang J.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Statut éditorial
Publié
Date de publication
15/01/2018
Peer-reviewed
Oui
Volume
9
Numéro
1
Pages
224
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
Health risk factors such as body mass index (BMI) and serum cholesterol are associated with many common diseases. It often remains unclear whether the risk factors are cause or consequence of disease, or whether the associations are the result of confounding. We develop and apply a method (called GSMR) that performs a multi-SNP Mendelian randomization analysis using summary-level data from genome-wide association studies to test the causal associations of BMI, waist-to-hip ratio, serum cholesterols, blood pressures, height, and years of schooling (EduYears) with common diseases (sample sizes of up to 405,072). We identify a number of causal associations including a protective effect of LDL-cholesterol against type-2 diabetes (T2D) that might explain the side effects of statins on T2D, a protective effect of EduYears against Alzheimer's disease, and bidirectional associations with opposite effects (e.g., higher BMI increases the risk of T2D but the effect of T2D on BMI is negative).
Mots-clé
Alzheimer Disease/blood, Alzheimer Disease/genetics, Body Mass Index, Cholesterol/blood, Cholesterol, LDL/blood, Diabetes Mellitus, Type 2/blood, Diabetes Mellitus, Type 2/genetics, Disease/etiology, Disease/genetics, Genome-Wide Association Study/methods, Humans, Mendelian Randomization Analysis, Polymorphism, Single Nucleotide, Risk Factors
Pubmed
Web of science
Open Access
Oui
Création de la notice
21/01/2019 11:46
Dernière modification de la notice
30/04/2021 7:08
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