Human Primary Auditory Cortex Follows the Shape of Heschl's Gyrus.

Détails

Ressource 1Télécharger: 14067.full.pdf (2374.68 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_0D629CC5C71E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Human Primary Auditory Cortex Follows the Shape of Heschl's Gyrus.
Périodique
Journal of Neuroscience
Auteur(s)
Da Costa S., van der Zwaag W., Marques J.P., Frackowiak R.S., Clarke S., Saenz M.
ISSN
1529-2401 (Electronic)
ISSN-L
0270-6474
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
31
Numéro
40
Pages
14067-14075
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
The primary auditory cortex (PAC) is central to human auditory abilities, yet its location in the brain remains unclear. We measured the two largest tonotopic subfields of PAC (hA1 and hR) using high-resolution functional MRI at 7 T relative to the underlying anatomy of Heschl's gyrus (HG) in 10 individual human subjects. The data reveals a clear anatomical-functional relationship that, for the first time, indicates the location of PAC across the range of common morphological variants of HG (single gyri, partial duplications, and complete duplications). In 20/20 individual hemispheres, two primary mirror-symmetric tonotopic maps were clearly observed with gradients perpendicular to HG. PAC spanned both divisions of HG in cases of partial and complete duplications (11/20 hemispheres), not only the anterior division as commonly assumed. Specifically, the central union of the two primary maps (the hA1-R border) was consistently centered on the full Heschl's structure: on the gyral crown of single HGs and within the sulcal divide of duplicated HGs. The anatomical-functional variants of PAC appear to be part of a continuum, rather than distinct subtypes. These findings significantly revise HG as a marker for human PAC and suggest that tonotopic maps may have shaped HG during human evolution. Tonotopic mappings were based on only 16 min of fMRI data acquisition, so these methods can be used as an initial mapping step in future experiments designed to probe the function of specific auditory fields.
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/10/2011 12:58
Dernière modification de la notice
20/08/2019 13:34
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