Debit sanguin regional et extraction de l'oxygene dans les muscles de la jambe chez le sujet normal et l'insuffisant arteriel. Etude de la distribution du C15O2 et de l'15O2 par tomographie a emission de positons. [Regional blood flow and oxygen consumption in the leg muscles of normal subjects and in those with arterial insufficiency. Study of the distribution of C15O2 and of 15O2 using positron emission tomography]

Détails

ID Serval
serval:BIB_0D4AEB9C6E1D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Debit sanguin regional et extraction de l'oxygene dans les muscles de la jambe chez le sujet normal et l'insuffisant arteriel. Etude de la distribution du C15O2 et de l'15O2 par tomographie a emission de positons. [Regional blood flow and oxygen consumption in the leg muscles of normal subjects and in those with arterial insufficiency. Study of the distribution of C15O2 and of 15O2 using positron emission tomography]
Périodique
Journal des Maladies Vasculaires
Auteur(s)
Depairon  M., Depresseux  J. C., De Landsheere  C., Merlo  P., Del Fiore  G., Quaglia  L., Peeters  J. M., Lamotte  D., Zicot  M.
ISSN
0398-0499 (Print)
Statut éditorial
Publié
Date de publication
1988
Volume
13
Numéro
2
Pages
107-15
Notes
English Abstract
Journal Article
Résumé
We first studied the distribution of radioactivity during continuous inhalation of C15O2 and 15O2 in traverse tomograms of the greatest diameter of legs, at rest and immediately after exercise (ankle flexions). C15O2 and 15O2 were distributed homogeneously and symmetrically in both legs of normal subjects at rest. The activity accumulated in the anterolateral region after exercise. In patients, this pattern of distribution was similar but asymmetrical, depending on the arterial pathology. No systematic distribution of either C15O2 or 15O2 was observed. In a second step, we studied quantitatively blood flow (F), oxygen uptake (R) and oxygen extraction (E) in 11 subjects: 5 normals (23 +/- 1 years) and 6 patients (60 +/- 11 years) suffering from unilateral intermittent claudication. We used the bolus inhalation technique of C15O2 and 15O2. In the normal leg at rest, ranges were 2.5 to 8.0 ml/min.hg for F, 0.9 to 21.3 mumol/min.hg for R and 3.6 to 33.4% for E. In the pathological leg at rest, ranges were 3.7 to 11.3 ml/min.hg for F, 3.8 to 10.6 mumol/min.hg for R and 7.1 to 24.5% for E. After exercise, ranges were 6.4 to 62.8 ml/min.hg for F, 66.0 to 386.3 mumol/min.hg for R and 29.2 to 89.5% for E in both legs. There was no straight difference between normal and pathological legs soon after exercise. This study allows us to expect that the demonstration of such a difference implies a longer delay of data acquisition following the slow post-ischemia recovery.
Mots-clé
Adult Aged Arterial Occlusive Diseases/*physiopathology Carbon Radioisotopes/diagnostic use Exertion Female Humans Intermittent Claudication/physiopathology Leg/*blood supply Male Middle Aged Muscles/*metabolism *Oxygen Consumption Oxygen Radioisotopes/diagnostic use Regional Blood Flow Tomography, Emission-Computed
Pubmed
Web of science
Création de la notice
17/01/2008 17:33
Dernière modification de la notice
20/08/2019 13:34
Données d'usage