Angiotensin II, vasopressin, and sympathetic activity in conscious rats with endotoxemia

Détails

ID Serval
serval:BIB_0D47382B561D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Angiotensin II, vasopressin, and sympathetic activity in conscious rats with endotoxemia
Périodique
American Journal of Physiology. Heart and Circulatory Physiology
Auteur(s)
Schaller  M. D., Waeber  B., Nussberger  J., Brunner  H. R.
ISSN
0363-6135
ISSN-L
0363-6135
Statut éditorial
Publié
Date de publication
12/1985
Volume
249
Numéro
6 Pt 2
Pages
H1086-92
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Dec
Résumé
The role of the sympathetic nervous system, angiotensin II (ANG II), and arginine vasopressin (AVP) in maintaining blood pressure (BP) during endotoxic shock was investigated in 117 conscious male Wistar rats. After intravenous injection of 2 mg Escherichia coli endotoxin, mean BP fell within 5 min by approximately 50 mmHg and rose again to approach base-line levels within 90 min. At that time, plasma renin activity, plasma norepinephrine (NE), and vasopressin levels of the endotoxin-treated animals were, respectively, 12-, 10-, and 54-fold (P less than 0.001) higher than those of the controls. The BP effect of either prazosin (0.125 mg iv), captopril (2.5 mg iv), or d(CH2)5Tyr(Me)AVP (5 micrograms iv), a specific antagonist of the vascular effect of AVP, was evaluated over a 30-min observation period starting 90 min after administration of endotoxin or its vehicle. Captopril reduced mean BP from 116 +/- 1.8 to a low of 109 +/- 2.1 (SE) mmHg (P less than 0.05, n = 8) only in rats pretreated with endotoxin, whereas the vasopressin antagonist had no depressor effect even during endotoxemia. The BP drop induced by prazosin in rats exposed to endotoxin (-21 +/- 3.3 mmHg, n = 6) did not significantly differ from that observed in control rats (-14 +/- 3.4 mmHg, n = 6). A dose-response curve to NE, ANG II, and lysine vasopressin was also performed. In endotoxin-treated rats the mean BP response to all agonists was markedly suppressed (P less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
Mots-clé
Angiotensin II/*physiology Animals Arginine Vasopressin/analogs & derivatives/pharmacology Blood Pressure/drug effects Captopril/pharmacology Endotoxins/pharmacology Epinephrine/blood Male Norepinephrine/blood Pentobarbital/pharmacology Prazosin/pharmacology Rats Rats, Inbred Strains Renin/blood Shock, Septic/*physiopathology Sympathetic Nervous System/*physiology Vasopressins/*physiology
Pubmed
Web of science
Création de la notice
05/03/2008 17:41
Dernière modification de la notice
20/08/2019 13:34
Données d'usage