Microglia at the Tripartite Synapse during Postnatal Development: Implications for Autism Spectrum Disorders and Schizophrenia.
Détails
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_0CF09E0EA2BE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Microglia at the Tripartite Synapse during Postnatal Development: Implications for Autism Spectrum Disorders and Schizophrenia.
Périodique
Cells
ISSN
2073-4409 (Electronic)
ISSN-L
2073-4409
Statut éditorial
Publié
Date de publication
13/12/2023
Peer-reviewed
Oui
Volume
12
Numéro
24
Pages
2827
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Publication Status: epublish
Résumé
Synapses are the fundamental structures of neural circuits that control brain functions and behavioral and cognitive processes. Synapses undergo formation, maturation, and elimination mainly during postnatal development via a complex interplay with neighboring astrocytes and microglia that, by shaping neural connectivity, may have a crucial role in the strengthening and weakening of synaptic functions, that is, the functional plasticity of synapses. Indeed, an increasing number of studies have unveiled the roles of microglia and astrocytes in synapse formation, maturation, and elimination as well as in regulating synaptic function. Over the past 15 years, the mechanisms underlying the microglia- and astrocytes-dependent regulation of synaptic plasticity have been thoroughly studied, and researchers have reported that the disruption of these glial cells in early postnatal development may underlie the cause of synaptic dysfunction that leads to neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia.
Mots-clé
Humans, Microglia/physiology, Autism Spectrum Disorder, Schizophrenia, Synapses/physiology, Neuroglia, astrocytes, autism, inflammation, microglia, schizophrenia, synaptic activity, tripartite synapse
Pubmed
Web of science
Open Access
Oui
Création de la notice
10/01/2024 12:03
Dernière modification de la notice
09/08/2024 15:55