Risk factors and outcomes for respiratory syncytial virus-related infections in immunocompromised children.

Détails

ID Serval
serval:BIB_0C783D0719CF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Risk factors and outcomes for respiratory syncytial virus-related infections in immunocompromised children.
Périodique
Pediatric Infectious Disease Journal
Auteur⸱e⸱s
Asner S., Stephens D., Pedulla P., Richardson S.E., Robinson J., Allen U.
ISSN
1532-0987 (Electronic)
ISSN-L
0891-3668
Statut éditorial
Publié
Date de publication
2013
Volume
32
Numéro
10
Pages
1073-1076
Langue
anglais
Notes
Publication types: Journal Article ; Observational Study ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
BACKGROUND: Respiratory syncytial virus (RSV) is associated with significant morbidity and mortality in immunocompromised children. Data on the risk factors for acquisition and outcomes from RSV infections in this population are limited.
METHODS: This cohort study (2006 to 2011) included RSV-positive immunocompromised pediatric inpatients. Nasopharyngeal swabs were tested for RSV by direct immunofluorescence. Purposeful multiple regression was used to assess risk factors associated with community-acquired RSV (CA-RSV) infections and their outcomes compared with nosocomial (N-RSV) infections. Means and medians were compared using Student's t test and a nonparametric test, respectively. Proportions were compared using χ(2) or Fisher's exact test, as appropriate.
RESULTS: There were 117 RSV-positive patients of whom 42 (35.9%) presented with (N-RSV) infection. Overall, more than a third presented with lower respiratory tract infections, which resulted in a 28% admission rate to the intensive care unit and a mortality rate of 5%; the latter solely among patients with community-acquired infection. Subjects with CA-RSV presented with more advanced clinical evidence of lower tract disease with respiratory distress (eg, intercostal recession; odds ratio 2.5; 95% confidence interval: 1.1-5.6; P = 0.03) compared with those with N-RSV. Subjects with CA-RSV infections were less likely to have a prolonged hospital admission (odds ratio 0.7; 95% confidence interval: 0.5-0.8; P < 0.0001) relative to those with N-RSV infections.
CONCLUSIONS: RSV-related infections in immunocompromised children may result in poor outcomes, including mortality. Differences in mortality rates among those with CA-RSV compared with N-RSV warrant further study, with enhanced opportunities for prevention and early detection of infection.
Mots-clé
Analysis of Variance, Child, Preschool, Cohort Studies, Cross Infection/drug therapy, Cross Infection/immunology, Female, Humans, Immunocompromised Host, Infant, Length of Stay, Male, Respiratory Syncytial Virus Infections/diagnosis, Respiratory Syncytial Virus Infections/drug therapy, Risk Factors, Treatment Outcome
Pubmed
Web of science
Création de la notice
30/06/2014 12:05
Dernière modification de la notice
20/08/2019 13:33
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