Reduced quality of life associated adverse events in intermediate hepatocellular carcinoma patients treated with PRECISION TACE with drug eluting beads: Results from the PRECISION V randomized trial : B-241
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ID Serval
serval:BIB_0C3A2F5996A8
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Institution
Titre
Reduced quality of life associated adverse events in intermediate hepatocellular carcinoma patients treated with PRECISION TACE with drug eluting beads: Results from the PRECISION V randomized trial : B-241
Titre de la conférence
ECR 2010, 22nd European Congress of Radiology
Adresse
Vienna, Austria, March 4-8, 2010
ISBN
1869-4101
Statut éditorial
Publié
Date de publication
2010
Volume
1
Série
Insights into Imaging
Pages
S183
Langue
anglais
Résumé
Purpose: To evaluate the extent of quality of life (QoL) associated adverse events
(AEs) following PRECISION TACE with DC Bead compared with conventional
transarterial chemoembolisation (cTACE).
Methods and Materials: 201 intermediate HCC patients were treated with DC
Bead (PRECISION TACE) or conventional TACE (cTACE) with doxorubicin in
the PRECISION V clinical study. 93 patients were treated with DC Bead and 108
Patients with cTACE every 2 months and followed up for 6 months. AEs were classified
according to the South West Oncology Group criteria. QoL associated AEs
were defined as alopecia, constipation, nausea, vomiting, pyrexia, chills, asthenia,
fatigue, and headache.
Results: The biggest difference in QoL associated AEs was for alopecia: 2 patients
(2.2%) for DC-Bead versus 21 patients (19.4%) for cTACE. For other clinical
symptoms, constipation (n=10; 10.8% vs. n=13; 12%), vomiting (n=10; 10.8% vs.
n=14; 13.0%), pyrexia (n=16; 17.2% vs. n=26; 24.1%), chills (n=1; 1.1% vs. n=5;
4.6%), and headache (n=2; 2.2% vs. n=8; 7.4%) showed lower incidence in the
DC Bead group versus cTACE. Nausea, n= 15; 13.9% (n=15; 16.1%) and fatigue,
n=6; 5.6% (n=13; 14.0%) were lower for cTACE. Total dose of doxorubicin was on
average 35% higher in the DC Bead group.
Conclusion: Although patients in the DC Bead group received a higher doxorubicin
dose, less QoL associated AEs were reported for this group. Alopecia, the most obvious
outward sign of toxicity, was only reported in a tenth of DC Bead patients. Thus,
PRECISION TACE with DC Bead improves quality of life associated adverse events.
(AEs) following PRECISION TACE with DC Bead compared with conventional
transarterial chemoembolisation (cTACE).
Methods and Materials: 201 intermediate HCC patients were treated with DC
Bead (PRECISION TACE) or conventional TACE (cTACE) with doxorubicin in
the PRECISION V clinical study. 93 patients were treated with DC Bead and 108
Patients with cTACE every 2 months and followed up for 6 months. AEs were classified
according to the South West Oncology Group criteria. QoL associated AEs
were defined as alopecia, constipation, nausea, vomiting, pyrexia, chills, asthenia,
fatigue, and headache.
Results: The biggest difference in QoL associated AEs was for alopecia: 2 patients
(2.2%) for DC-Bead versus 21 patients (19.4%) for cTACE. For other clinical
symptoms, constipation (n=10; 10.8% vs. n=13; 12%), vomiting (n=10; 10.8% vs.
n=14; 13.0%), pyrexia (n=16; 17.2% vs. n=26; 24.1%), chills (n=1; 1.1% vs. n=5;
4.6%), and headache (n=2; 2.2% vs. n=8; 7.4%) showed lower incidence in the
DC Bead group versus cTACE. Nausea, n= 15; 13.9% (n=15; 16.1%) and fatigue,
n=6; 5.6% (n=13; 14.0%) were lower for cTACE. Total dose of doxorubicin was on
average 35% higher in the DC Bead group.
Conclusion: Although patients in the DC Bead group received a higher doxorubicin
dose, less QoL associated AEs were reported for this group. Alopecia, the most obvious
outward sign of toxicity, was only reported in a tenth of DC Bead patients. Thus,
PRECISION TACE with DC Bead improves quality of life associated adverse events.
Site de l'éditeur
Création de la notice
28/07/2010 8:14
Dernière modification de la notice
20/08/2019 13:33
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