Cerebrospinal fluid antimicroglial antibodies in Alzheimer disease: a putative marker of an ongoing inflammatory process.

Détails

ID Serval
serval:BIB_0C2248065338
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Cerebrospinal fluid antimicroglial antibodies in Alzheimer disease: a putative marker of an ongoing inflammatory process.
Périodique
Experimental gerontology
Auteur(s)
McRae A., Martins R.N., Fonte J., Kraftsik R., Hirt L., Miklossy J.
ISSN
0531-5565
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
42
Numéro
4
Pages
355-63
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
Immunocompetent microglia play an important role in the pathogenesis of Alzheimer's disease (AD). Antimicroglial antibodies in the cerebrospinal fluid (CSF) in clinically diagnosed AD patients have been previously recorded. Here, we report the results of the analysis of the CSF from 38 autopsy cases: 7 with definite AD; 14 with mild and 10 with moderate Alzheimer's type pathology; and 7 controls. Antimicroglial antibodies were identified in 70% of patients with definite AD, in 80% of patients with moderate and in 28% of patients with mild Alzheimer's type pathology. CSF antimicroglial antibodies were not observed in any of the control cases. The results show that CSF antimicroglial antibodies are present in the majority of patients with definite AD and also in cases with moderate Alzheimer's type changes. They may also indicate dysregulation of microglial function. Together with previous observations, these findings indicate that compromised immune defense mechanisms play an important role in the pathogenesis of AD.
Mots-clé
Aged, Aged, 80 and over, Alzheimer Disease, Amyloid beta-Protein, Antibodies, Autopsy, Biological Markers, Cells, Cultured, Cerebral Cortex, Female, Humans, Immunohistochemistry, Inflammation, Male, Microglia, Middle Aged
Pubmed
Web of science
Création de la notice
26/02/2008 16:25
Dernière modification de la notice
20/08/2019 12:33
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