No Evidence for Association of β-Defensin Genomic Copy Number with HIV Susceptibility, HIV Load during Clinical Latency, or Progression to AIDS.

Détails

ID Serval
serval:BIB_0C137198D58A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
No Evidence for Association of β-Defensin Genomic Copy Number with HIV Susceptibility, HIV Load during Clinical Latency, or Progression to AIDS.
Périodique
Annals of human genetics
Auteur(s)
Abujaber R., Shea P.R., McLaren P.J., Lakhi S., Gilmour J., Allen S., Fellay J., Hollox E.J.
Collaborateur(s)
IAVI Africa HIV Prevention Partnership, Swiss HIV Cohort Study
ISSN
1469-1809 (Electronic)
ISSN-L
0003-4800
Statut éditorial
Publié
Date de publication
01/2017
Peer-reviewed
Oui
Volume
81
Numéro
1
Pages
27-34
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Common single-nucleotide variation in the host accounts for 25% of the variability in the plasma levels of HIV during the clinical latency stage (viral load set point). However, the role of rare variants and copy number variants remains relatively unexplored. Previous work has suggested copy number variation of a cluster of β-defensin genes affects HIV load in treatment-naïve sub-Saharan Africans and rate of response to antiretroviral treatment. Here we analyse a total of 1827 individuals from two cohorts of HIV-infected individuals from Europe and sub-Saharan Africa to investigate the role of β-defensin copy number variation on HIV load at set point. We find no evidence for association of copy number with viral load. We also compare distribution of β-defensin copy number between European cases and controls and find no differences, arguing against a role of β-defensin copy number in HIV acquisition. Taken together, our data argue against an effect of copy number variation of the β-defensin region in the spontaneous control of HIV infection.
Mots-clé
Acquired Immunodeficiency Syndrome/genetics, Acquired Immunodeficiency Syndrome/virology, Adult, DNA Copy Number Variations, Disease Progression, Female, Gene Dosage, Genetic Association Studies, Genetic Predisposition to Disease, HIV-1/physiology, Humans, Male, Middle Aged, Viral Load, beta-Defensins/genetics, AIDS, CNV, HIV-1, copy number variation, β-defensin
Pubmed
Web of science
Création de la notice
19/10/2017 9:03
Dernière modification de la notice
15/07/2020 5:26
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