Spontaneous cell polarization: Feedback control of Cdc42 GTPase breaks cellular symmetry.

Détails

Ressource 1Télécharger: BIB_0C0D95AB3528.P001.pdf (1367.98 [Ko])
Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_0C0D95AB3528
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Spontaneous cell polarization: Feedback control of Cdc42 GTPase breaks cellular symmetry.
Périodique
Bioessays : News and Reviews In Molecular, Cellular and Developmental Biology
Auteur(s)
Martin S.G.
ISSN
1521-1878 (Electronic)
ISSN-L
0265-9247
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
37
Numéro
11
Pages
1193-1201
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish
Résumé
Spontaneous polarization without spatial cues, or symmetry breaking, is a fundamental problem of spatial organization in biological systems. This question has been extensively studied using yeast models, which revealed the central role of the small GTPase switch Cdc42. Active Cdc42-GTP forms a coherent patch at the cell cortex, thought to result from amplification of a small initial stochastic inhomogeneity through positive feedback mechanisms, which induces cell polarization. Here, I review and discuss the mechanisms of Cdc42 activity self-amplification and dynamic turnover. A robust Cdc42 patch is formed through the combined effects of Cdc42 activity promoting its own activation and active Cdc42-GTP displaying reduced membrane detachment and lateral diffusion compared to inactive Cdc42-GDP. I argue the role of the actin cytoskeleton in symmetry breaking is not primarily to transport Cdc42 to the active site. Finally, negative feedback and competition mechanisms serve to control the number of polarization sites.
Mots-clé
Actin Cytoskeleton/metabolism, Cell Polarity/physiology, Feedback, Guanosine Triphosphate/chemistry, Models, Biological, Protein Transport, Saccharomyces cerevisiae/metabolism, Schizosaccharomyces/metabolism, Transport Vesicles/metabolism, cdc42 GTP-Binding Protein, Saccharomyces cerevisiae/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
13/11/2015 8:08
Dernière modification de la notice
20/08/2019 12:33
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