The fragile X mental retardation protein regulates tumor invasiveness-related pathways in melanoma cells.

Détails

Ressource 1Télécharger: 29144507_BIB_0BD6585AD298.pdf (3981.59 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_0BD6585AD298
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The fragile X mental retardation protein regulates tumor invasiveness-related pathways in melanoma cells.
Périodique
Cell death & disease
Auteur(s)
Zalfa F., Panasiti V., Carotti S., Zingariello M., Perrone G., Sancillo L., Pacini L., Luciani F., Roberti V., D'Amico S., Coppola R., Abate S.O., Rana R.A., De Luca A., Fiers M., Melocchi V., Bianchi F., Farace M.G., Achsel T., Marine J.C., Morini S., Bagni C.
ISSN
2041-4889 (Electronic)
Statut éditorial
Publié
Date de publication
16/11/2017
Peer-reviewed
Oui
Volume
8
Numéro
11
Pages
e3169
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
The fragile X mental retardation protein (FMRP) is lacking or mutated in patients with the fragile X syndrome (FXS), the most frequent form of inherited intellectual disability. FMRP affects metastasis formation in a mouse model for breast cancer. Here we show that FMRP is overexpressed in human melanoma with high Breslow thickness and high Clark level. Furthermore, meta-analysis of the TCGA melanoma data revealed that high levels of FMRP expression correlate significantly with metastatic tumor tissues, risk of relapsing and disease-free survival. Reduction of FMRP in metastatic melanoma cell lines impinges on cell migration, invasion and adhesion. Next-generation sequencing in human melanoma cells revealed that FMRP regulates a large number of mRNAs involved in relevant processes of melanoma progression. Our findings suggest an association between FMRP levels and the invasive phenotype in melanoma and might open new avenues towards the discovery of novel therapeutic targets.
Mots-clé
Fragile X Mental Retardation Protein/genetics, Fragile X Mental Retardation Protein/metabolism, Humans, Melanoma/metabolism, Melanoma/pathology, Neoplasm Invasiveness, Transfection
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/11/2017 11:56
Dernière modification de la notice
30/04/2021 7:08
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