Effect of cardiopulmonary bypass and heparin on plasma levels of Lp(a) and Apo(a) fragments.

Détails

ID Serval
serval:BIB_0BD0E3430FF4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effect of cardiopulmonary bypass and heparin on plasma levels of Lp(a) and Apo(a) fragments.
Périodique
Arteriosclerosis, Thrombosis, and Vascular Biology
Auteur⸱e⸱s
Mooser V., Tinguely F., Fontana P., Lenain V., Vaglio M., Ruchat P., von Segesser L.K., Marcovina S.M., Markert M., Darioli R., Nicod P.
ISSN
1079-5642
Statut éditorial
Publié
Date de publication
1999
Peer-reviewed
Oui
Volume
19
Numéro
4
Pages
1060-1065
Langue
anglais
Notes
Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. --- Old month value: Apr
Résumé
Fragments of apolipoprotein(a) [apo(a)], the distinctive glycoprotein of lipoprotein(a) [Lp(a)], are present in human plasma and urine and have been implicated in the development of atherosclerosis. The mechanism responsible for the generation of apo(a) fragments in vivo is poorly understood. In this study, we examined the plasma levels of Lp(a) and apo(a) fragments [or free apo(a)] and urinary apo(a) in 15 subjects who underwent cardiac surgery necessitating cardiopulmonary bypass. We also measured the plasma concentration and activity of polymorphonuclear elastase, an Lp(a)-cleaving enzyme in vitro, and plasma levels of C-reactive protein. Despite a marked activation of polymorphonuclear cells and a pronounced inflammatory response, as documented by an 8-fold and a 35-fold increase in plasma levels of polymorphonuclear elastase and C-reactive protein, respectively, the proportion of plasma free apo(a) to Lp(a) and urinary excretion of apo(a) remained unchanged over a 7-day period after surgery, and polymorphonuclear elastase activity remained undetectable in plasma. No fragmentation of apo(a) was observed ex vivo in plasma samples collected before and after surgery. These data indicate that in this model, apo(a) is not fragmented in plasma and are consistent with the hypothesis that apo(a) fragments result from a constitutively active tissue mechanism that is not modified by cardiac surgery with cardiopulmonary bypass.
Mots-clé
Aged, Apolipoproteins A, Cardiopulmonary Bypass, Female, Heparin, Humans, Injections, Intravenous, Lipoprotein(a), Male, Middle Aged
Pubmed
Web of science
Création de la notice
28/01/2008 11:45
Dernière modification de la notice
20/08/2019 12:33
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