Testing human hair for carbamazepine in epileptic patients: is hair investigation suitable for drug monitoring?

Détails

ID Serval
serval:BIB_0B8ABB41B8A8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Testing human hair for carbamazepine in epileptic patients: is hair investigation suitable for drug monitoring?
Périodique
Human and Experimental Toxicology
Auteur(s)
Kintz P., Marescaux C., Mangin P.
ISSN
0960-3271[print], 0960-3271[linking]
Statut éditorial
Publié
Date de publication
1995
Volume
14
Numéro
10
Pages
812-815
Langue
anglais
Résumé
Hair samples were obtained from 30 patients who had been taking carbamazepine in fixed daily doses for more than 6 months. Carbamazepine was extracted from the hair by enzymatic hydrolysis and quantified by gas chromatography-mass spectrometry. Concentrations ranged from 1.2 to 57.4 ng mg-1. The concentrations of carbamazepine were significantly correlated (P < 0.0001) with the daily dose and the correlation coefficient was 0.793. Although it had been suggested by several authors that the measurement of carbamazepine in hair might provide a better index of individual dosage history than the plasma level assays, the deviations observed in this study led to the conclusion that hair samples are not suitable for evaluating the quantity of drug consumed. However, hair testing may be useful for documenting clinical disorders by sectioning the shaft into segments corresponding to 1 month periods.
Mots-clé
Anticonvulsants/administration & dosage, Anticonvulsants/analysis, Carbamazepine/administration & dosage, Carbamazepine/analysis, Drug Monitoring/methods, Epilepsy/drug therapy, Epilepsy/metabolism, Gas Chromatography-Mass Spectrometry, Hair/chemistry, Humans, Patient Compliance, Tissue Distribution
Pubmed
Création de la notice
19/10/2010 16:31
Dernière modification de la notice
20/08/2019 13:33
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