Absorption and preferential vagina-to-uterus distribution after vaginal administration of (99m)Tc-pertechnetate in postmenopausal women

Détails

ID Serval
serval:BIB_0B79B5149129
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Absorption and preferential vagina-to-uterus distribution after vaginal administration of (99m)Tc-pertechnetate in postmenopausal women
Périodique
Fertility and Sterility
Auteur(s)
Cicinelli  E., Rubini  G., De Ziegler  D., Barba  B., Pinto  V., Di Stefano  M. G., Mele  M.
ISSN
0015-0282
Statut éditorial
Publié
Date de publication
12/2001
Peer-reviewed
Oui
Volume
76
Numéro
6
Pages
1108-12
Notes
Clinical Trial
Controlled Clinical Trial
Journal Article --- Old month value: Dec
Résumé
OBJECTIVE: To investigate in vivo and in humans the mechanisms and kinetics of vagina-to-uterus distribution. DESIGN: Controlled clinical study. SETTING: Volunteers in an academic research environment. PATIENT(S): Six postmenopausal women undergoing transabdominal hysterectomy were selected.Intervention(s): Women received 0.2 mL of (99m)Tc-pertechnetate vaginally. In three patients the cervical canal was previously sealed by means of surgical glue. Six postmenopausal women who had received (99m)Tc-pertechnetate intravenously for a thyroid scintigraphy were considered as a control. MAIN OUTCOME MEASURE(S): Radioactivity was assessed every 30 minutes for 6 hours in the pelvis and in body regions where (99m)Tc-pertechnetate normally accumulates (thyroid, salivary glands, and stomach). RESULT(S): Uterine activity appeared after 60 minutes and peaked between 120 to 210 minutes. These same times were observed in the patients who had a sealed cervix. Thyroid uptake appeared after 180 minutes and peaked between 210 and 330 minutes. Uterine uptake did not occur in any of the intravenous patients; their thyroid uptake was rapid, appearing after 30 minutes. CONCLUSION(S): Preferential vagina-to-uterus distribution, at least in postmenopausal women, is not simply due an intracanalicular passage but is mediated by absorption of substances and probably by a countercurrent transfer mechanism.
Mots-clé
Absorption Administration, Intravaginal Female Humans Pilot Projects Postmenopause Radiopharmaceuticals/administration & dosage/*pharmacokinetics Salivary Glands/radionuclide imaging Sodium Pertechnetate Tc 99m/administration & dosage/*pharmacokinetics Stomach/radionuclide imaging Thyroid Gland/radionuclide imaging Uterus/*metabolism/radionuclide imaging Vagina/drug effects/*metabolism/radionuclide imaging
Pubmed
Web of science
Création de la notice
28/02/2008 12:37
Dernière modification de la notice
20/08/2019 13:33
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