Intraepithelial T cells and tumor proliferation: impact on the benefit from surgical cytoreduction in advanced serous ovarian cancer.

Détails

ID Serval
serval:BIB_0B79AADD09E7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Intraepithelial T cells and tumor proliferation: impact on the benefit from surgical cytoreduction in advanced serous ovarian cancer.
Périodique
Cancer
Auteur⸱e⸱s
Adams S.F., Levine D.A., Cadungog M.G., Hammond R., Facciabene A., Olvera N., Rubin S.C., Boyd J., Gimotty P.A., Coukos G.
ISSN
0008-543X (Print)
ISSN-L
0008-543X
Statut éditorial
Publié
Date de publication
2009
Volume
115
Numéro
13
Pages
2891-2902
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
BACKGROUND: The aim of the study was to determine whether tumor-infiltrating lymphocytes and/or tumor mitotic activity could identify subgroups of patients with advanced serous epithelial ovarian cancer who would maximally benefit from aggressive surgical cytoreduction.
METHODS: Snap-frozen specimens from 134 consecutive patients with stage III or IV serous or poorly differentiated ovarian adenocarcinoma undergoing primary debulking surgery from a single US institution were characterized based on CD3(+), CD8(+), FoxP3(+) tumor-infiltrating lymphocytes, and Ki67 expression. Kaplan-Meier survival curves were estimated and compared using a log-rank statistic. A multivariate Cox model was used to estimate adjusted hazard ratios. Interactions were modeled using recursive partitioning based on maximal prognostic differentiation.
RESULTS: Brisk intraepithelial CD8(+) cells (P = .035) and low Ki67 expression (P = .042) portended prolonged survival. The T-cell infiltration was more likely to occur in tumors with high proliferation index. Patients whose tumors exhibited low Ki67 expression and high intraepithelial CD8(+) frequency had a 5-year survival rate of 73.3%. Patients with aggressive tumor behavior, that is, whose tumors exhibited low frequency of intraepithelial CD8(+) T cells or high Ki67 expression were more likely to draw benefit from aggressive surgical cytoreduction. Survival was similar for patients with brisk CD8(+) T cells who had optimal or suboptimal debulking. Likewise, survival was similar for patients with low Ki67 expression who had optimal or suboptimal debulking.
CONCLUSIONS: For the first time, these novel interactions of T cells, tumor proliferation index, and surgical treatment reveal that biological prognosticators may be useful for surgical decision making in ovarian cancer.
Mots-clé
Adult, Aged, Aged, 80 and over, Antigens, CD3/analysis, CD8-Positive T-Lymphocytes, Cell Proliferation, Cystadenoma, Serous/immunology, Cystadenoma, Serous/pathology, Female, Forkhead Transcription Factors/analysis, Humans, Ki-67 Antigen/analysis, Lymphocytes, Tumor-Infiltrating/immunology, Middle Aged, Ovarian Neoplasms/immunology, Ovarian Neoplasms/pathology, Prognosis, T-Lymphocytes, Treatment Outcome
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/10/2014 12:43
Dernière modification de la notice
20/08/2019 13:33
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