Evolutionary genomics and HIV restriction factors.

Détails

ID Serval
serval:BIB_0B71BB6C37A0
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Evolutionary genomics and HIV restriction factors.
Périodique
Current Opinion in HIV and Aids
Auteur⸱e⸱s
Pyndiah N., Telenti A., Rausell A.
ISSN
1746-6318 (Electronic)
ISSN-L
1746-630X
Statut éditorial
Publié
Date de publication
2015
Volume
10
Numéro
2
Pages
79-83
Langue
anglais
Résumé
PURPOSE OF REVIEW: To provide updated insights into innate antiviral immunity and highlight prototypical evolutionary features of well characterized HIV restriction factors.
RECENT FINDINGS: Recently, a new HIV restriction factor, Myxovirus resistance 2, has been discovered and the region/residue responsible for its activity identified using an evolutionary approach. Furthermore, IFI16, an innate immunity protein known to sense several viruses, has been shown to contribute to the defense to HIV-1 by causing cell death upon sensing HIV-1 DNA.
SUMMARY: Restriction factors against HIV show characteristic signatures of positive selection. Different patterns of accelerated sequence evolution can distinguish antiviral strategies--offense or defence--as well as the level of specificity of the antiviral properties. Sequence analysis of primate orthologs of restriction factors serves to localize functional domains and sites responsible for antiviral action. We use recent discoveries to illustrate how evolutionary genomic analyses help identify new antiviral genes and their mechanisms of action.
Pubmed
Web of science
Création de la notice
13/03/2015 19:08
Dernière modification de la notice
20/08/2019 12:33
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