Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production.

Détails

ID Serval
serval:BIB_0B371CFE3C3D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production.
Périodique
Nature Immunology
Auteur(s)
Poeck H., Bscheider M., Gross O., Finger K., Roth S., Rebsamen M., Hannesschläger N., Schlee M., Rothenfusser S., Barchet W., Kato H., Akira S., Inoue S., Endres S., Peschel C., Hartmann G., Hornung V., Ruland J.
ISSN
1529-2916[electronic], 1529-2908[linking]
Statut éditorial
Publié
Date de publication
2010
Peer-reviewed
Oui
Volume
11
Numéro
1
Pages
63-69
Langue
anglais
Résumé
Interleukin 1 beta (IL-1 beta) is a potent proinflammatory factor during viral infection. Its production is tightly controlled by transcription of Il1b dependent on the transcription factor NF-kappaB and subsequent processing of pro-IL-1 beta by an inflammasome. However, the sensors and mechanisms that facilitate RNA virus-induced production of IL-1 beta are not well defined. Here we report a dual role for the RNA helicase RIG-I in RNA virus-induced proinflammatory responses. Whereas RIG-I-mediated activation of NF-kappaB required the signaling adaptor MAVS and a complex of the adaptors CARD9 and Bcl-10, RIG-I also bound to the adaptor ASC to trigger caspase-1-dependent inflammasome activation by a mechanism independent of MAVS, CARD9 and the Nod-like receptor protein NLRP3. Our results identify the CARD9-Bcl-10 module as an essential component of the RIG-I-dependent proinflammatory response and establish RIG-I as a sensor able to activate the inflammasome in response to certain RNA viruses.
Mots-clé
Adaptor Proteins, Signal Transducing/genetics, Adaptor Proteins, Signal Transducing/metabolism, Animals, Caspase 1/metabolism, Cell Line, Cells, Cultured, DEAD-box RNA Helicases/genetics, DEAD-box RNA Helicases/metabolism, Encephalomyocarditis virus/immunology, Encephalomyocarditis virus/physiology, Enzyme Activation, Enzyme-Linked Immunosorbent Assay, Host-Pathogen Interactions, Humans, Immunoblotting, Inflammation/immunology, Inflammation/physiopathology, Interleukin-1beta/metabolism, Mice, Mice, Knockout, Models, Biological, RNA Virus Infections/immunology, RNA Virus Infections/physiopathology, RNA Viruses/immunology, RNA Viruses/physiology, Signal Transduction, Vesicular stomatitis Indiana virus/immunology, Vesicular stomatitis Indiana virus/physiology, bcl-X Protein/genetics, bcl-X Protein/metabolism
Pubmed
Web of science
Création de la notice
26/11/2010 12:46
Dernière modification de la notice
20/08/2019 13:32
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