No healthy heart for heavy drinkers: a population-based study in Switzerland

Détails

ID Serval
serval:BIB_0B2A4FF17E2E
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Institution
Titre
No healthy heart for heavy drinkers: a population-based study in Switzerland
Titre de la conférence
76e Assemblée annuelle de la Société suisse de médecine interne (SGIM/SSMI)
Auteur⸱e⸱s
Foerster Maryline, Marques-Vidal Pedro Manuel, Gmel Gerhard, Daeppen Jean-Bernard, Cornuz Jacques, Hayoz Daniel, Pécoud Alain, Mooser Vincent, Waeber Gérard, Vollenweider Peter, Paccaud Fred, Rodondi Nicolas
Adresse
Lausanne, Suisse, 21-23 mai 2008
ISBN
1424-3784
Statut éditorial
Publié
Date de publication
2008
Volume
8
Série
Swiss Medical Forum = Forum Médical Suisse
Pages
9S
Langue
anglais
Résumé
Background: Low to moderate alcohol consumption has been associated with lower coronary heart disease (CHD) risk, an effect mainly mediated by an increase in HDL-cholesterol levels. However, data on the CHD risk associated with high alcohol consumption are conflicting.
Methods: In a population-based study of 5,769 men and women, aged 35-75 years, without cardiovascular disease in Switzerland, last week alcohol consumption was categorized into 0, 1-6, 7-13, 14-20, 21-27, 28-34, 035 drinks/week and into nondrinkers (0 drink/week), moderate (1-13), high (14-34) and very high drinkers (035). Blood pressure, lipids and high sensitivity C-reactive protein (hs-CRP) were measured, and the 10-year CHD risk was calculated according to the Framingham risk score.
Results: 73% (n = 4,214) of the participants consumed alcohol; 16% (n = 909) were considered as high drinkers and 2% (n = 119) as very high drinkers. In multivariate analysis, increasing alcohol consumption was associated with higher HDL-cholesterol (from 1.57 ± 0.01 [adjusted mean ± SE] in nondrinkers to 1.88 ± 0.03 mmol/L in very high drinkers); triglycerides (1.17 ± 1.01 to 1.32 ± 1.05 mmol/L), and systolic and diastolic blood pressure rose significantly (127.4 ± 0.4 to 132.2 ± 1.4 and 78.7 ± 0.3 to 81.7 ± 0.9 mm Hg, respectively, all p for trend <0.001). Predicted 10-year CHD risk increased from 4.31 ± 0.10 to 4.90 ± 0.37 (p = 0.03) with increasing alcohol use, with a J-shaped relationship.
Conclusion: As measured by the 10-year CHD risk, the protective effect of alcohol consumption disappears in very high drinkers, namely because the beneficial increase in HDL-cholesterol may be blunt by a rise in blood pressure levels.
Création de la notice
03/03/2009 11:10
Dernière modification de la notice
20/08/2019 12:32
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