Combined effect of tobacco smoking and alcohol drinking in the risk of head and neck cancers : a re-analysis of case-control studies using bi-dimensional spline models

Détails

ID Serval
serval:BIB_0B22DEBC531D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Combined effect of tobacco smoking and alcohol drinking in the risk of head and neck cancers : a re-analysis of case-control studies using bi-dimensional spline models
Périodique
European Journal of Epidemiology
Auteur⸱e⸱s
Dal Maso L., Torelli N., Biancotto E., Di Maso M., Gini A., Franchin G., Levi F., La Vecchia C., Serraino D., Polesel J.
ISSN
1573-7284 (Electronic)
ISSN-L
0393-2990
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
31
Numéro
4
Pages
385-393
Langue
anglais
Résumé
The synergistic effect of tobacco smoking and alcohol consumption on the risk of head and neck cancers has been mainly investigated as a cross-product of categorical exposure, thus leading to loss of information. We propose a bi-dimensional logistic spline model to investigate the interacting dose-response relationship of two continuous exposures (i.e., ethanol intake and tobacco smoking) on the risk of head and neck cancers, representing results through three-dimensional graphs. This model was applied to a pool of hospital-based case-control studies on head and neck cancers conducted in Italy and in the Vaud Swiss Canton between 1982 and 2000, including 1569 cases and 3147 controls. Among never drinkers and for all levels of ethanol intake, the risk of head and neck cancers steeply increased with increasing smoking intensity, starting from 1 cigarette/day. The risk associated to ethanol intake increased with incrementing exposure among smokers, and a threshold effect at approximately 50 g/day emerged among never smokers. Compared to abstainers from both tobacco and alcohol consumption, the combined exposure to ethanol and/or cigarettes led to a steep increase of cancer risk up to a 35-fold higher risk (95 % confidence interval 27.30-43.61) among people consuming 84 g/day of ethanol and 10 cigarettes/day. The highest risk was observed at the highest levels of alcohol and tobacco consumption. Our findings confirmed a combined effect of tobacco smoking and alcohol drinking on head and neck cancers risk, providing evidence that bi-dimensional spline models could be a feasible and flexible method to explore the pattern of risks associated to two interacting continuous-exposure variables.
Pubmed
Web of science
Création de la notice
23/04/2015 12:39
Dernière modification de la notice
20/08/2019 12:32
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