Transient postnatal over nutrition induces long-term alterations in cardiac NLRP3-inflammasome pathway.

Détails

ID Serval
serval:BIB_0B0A73E62D1A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Transient postnatal over nutrition induces long-term alterations in cardiac NLRP3-inflammasome pathway.
Périodique
Nutrition, metabolism, and cardiovascular diseases
Auteur⸱e⸱s
Siddeek B., Li N., Mauduit C., Chehade H., Rigal E., Tolsa J.F., Armengaud J.B., Yzydorczyk C., Benahmed M., Vergely C., Simeoni U.
ISSN
1590-3729 (Electronic)
ISSN-L
0939-4753
Statut éditorial
Publié
Date de publication
09/2018
Peer-reviewed
Oui
Volume
28
Numéro
9
Pages
944-951
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The prevalence of obesity is increasing worldwide at an alarming rate. Altered early nutrition, in particular postnatal overfeeding (PNOF), is a risk factor for impaired cardiac function in adulthood. In the understanding of the initiation or progression of heart diseases, NLRP3 inflammasome and non-coding RNAs have been proposed as key players. In this context, the aim of this study was to decipher the role of NLRP3 inflammasome and its post transcriptional control by micro-RNAs in the regulation of cardiac metabolic function induced by PNOF in mice.
Based on a model of mice exposed to PNOF through litter size reduction, we observed increased cardiac protein expression levels of NLRP3 and ETS-1 associated with alterations in insulin signaling. Additionally, miR-193b levels were down-regulated in the adult hearts of overfed animals. In a cardiomyocyte cell line, transfection with miR-193b induced down-regulation of ETS-1 and NLRP3 and improved insulin signaling.
These findings suggest that the miR-193b could be involved in cardiac phenotypic changes observed in adulthood induced by PNOF likely through the regulation of ETS-1 and NLRP3 expression, and through this of insulin signaling.
Mots-clé
Animal Nutritional Physiological Phenomena, Animals, Animals, Newborn, Cell Line, Disease Models, Animal, Heart Diseases/etiology, Heart Diseases/genetics, Heart Diseases/metabolism, Heart Diseases/physiopathology, Inflammasomes/metabolism, Insulin/metabolism, Litter Size, Mice, Inbred C57BL, MicroRNAs/genetics, MicroRNAs/metabolism, Myocardium/metabolism, NLR Family, Pyrin Domain-Containing 3 Protein/metabolism, Nutritional Status, Overnutrition/complications, Overnutrition/genetics, Overnutrition/metabolism, Overnutrition/physiopathology, Proto-Oncogene Protein c-ets-1/metabolism, Rats, Signal Transduction, Time Factors, Cardiac dysfunctions, Inflammasome, Micro-RNAs, Nutrition
Pubmed
Web of science
Création de la notice
17/05/2018 19:16
Dernière modification de la notice
20/08/2019 13:32
Données d'usage