Developmental origins of chronic renal disease: an integrative hypothesis.

Détails

ID Serval
serval:BIB_0B0A25D98FE6
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Developmental origins of chronic renal disease: an integrative hypothesis.
Périodique
International Journal of Nephrology
Auteur⸱e⸱s
Boubred F., Saint-Faust M., Buffat C., Ligi I., Grandvuillemin I., Simeoni U.
ISSN
2090-214X (Print)
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
2013
Pages
346067
Langue
anglais
Notes
Publication types: Journal Article ; Review Publication Status: ppublish, pdf : Review Article
Résumé
Cardiovascular diseases are one of the leading causes of mortality. Hypertension (HT) is one of the principal risk factors associated with death. Chronic kidney disease (CKD), which is probably underestimated, increases the risk and the severity of adverse cardiovascular events. It is now recognized that low birth weight is a risk factor for these diseases, and this relationship is amplified by a rapid catch-up growth or overfeeding during infancy or childhood. The pathophysiological and molecular mechanisms involved in the "early programming" of CKD are multiple and partially understood. It has been proposed that the developmental programming of arterial hypertension and chronic kidney disease is related to a reduced nephron endowment. However, this mechanism is still discussed. This review discusses the complex relationship between birth weight and nephron endowment and how early growth and nutrition influence long term HT and CKD. We hypothesize that fetal environment reduces moderately the nephron number which appears insufficient by itself to induce long term diseases. Reduced nephron number constitutes a "factor of vulnerability" when additional factors, in particular a rapid postnatal growth or overfeeding, promote the early onset of diseases through a complex combination of various pathophysiological pathways.
Pubmed
Open Access
Oui
Création de la notice
21/02/2015 15:56
Dernière modification de la notice
20/08/2019 13:32
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