Impact of lamivudine on the risk of liver-related death in 2,041 HBsAg- and HIV-positive individuals: results from an inter-cohort analysis
Détails
ID Serval
serval:BIB_0AEDB213C1C3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Impact of lamivudine on the risk of liver-related death in 2,041 HBsAg- and HIV-positive individuals: results from an inter-cohort analysis
Périodique
Antiviral Therapy
ISSN
1359-6535 (Print)
Statut éditorial
Publié
Date de publication
2006
Volume
11
Numéro
5
Pages
567-74
Notes
Journal Article
Résumé
BACKGROUND: The impact of lamivudine (3TC) as part of combination antiretroviral therapy (cART) on the risk of liver-related death (LRD) in HIV/hepatitis B virus (HBV)-coinfected patients has not been extensively studied. METHODS: We performed an analysis involving HIV/HBV-coinfected patients in 13 cohorts who initiated cART. The end-point was LRD--that is, death with concomitant decompensated liver disease (DLD) or hepatocellular carcinoma--as the main cause. Incidence rates of LRD after initiation of cART were expressed as number of events per 100 person-years of follow-up (PYFU). A Poisson regression model adjusted for cohort, gender, mode of HIV transmission, CD4+ T-cell count at cART initiation, liver disease pre-cART, duration of 3TC before cART, and hepatitis C virus was used to assess the association between use of 3TC and risk of LRD. Results: We analysed 2,041 patients. Follow-up after starting cART was 7,648 PYFU (5,569 spent on 3TC-containing regimens) with a median per person of 48 months (range: 2-91). Of the total, 217 subjects died; 57 deaths were liver-related resulting in a rate of 7.5 per 1,000 PYFU [95% confidence intervals (CI): 5.6-9.7]. The relative risk of LRD per extra year of 3TC use was 0.73 (95% CI: 0.59-0.90, P = 0.004). CONCLUSION: The use of 3TC was associated with a reduced risk of LRD over 4 years of follow-up. This study supports the current view that the use of 3TC as part of cART should be considered in patients who are tested positive for HBsAg.
Mots-clé
Adult
CD4 Lymphocyte Count
Carcinoma, Hepatocellular/*drug therapy/immunology/mortality
Drug Therapy, Combination
Female
HIV Infections/*drug therapy/immunology/mortality
Hepatitis B/*drug therapy/immunology/mortality
Hepatitis B Surface Antigens/blood
Hepatitis C Antibodies/blood
Humans
Lamivudine/*therapeutic use
Liver Neoplasms/*drug therapy/immunology/mortality
Male
Retrospective Studies
Reverse Transcriptase Inhibitors/*therapeutic use
Risk Factors
Survival Analysis
Pubmed
Web of science
Création de la notice
29/01/2008 9:52
Dernière modification de la notice
20/08/2019 13:32