Involvement of hypothalamic dopamine in the regulation of prolactin secretion

Détails

ID Serval
serval:BIB_0AE1752C9526
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Involvement of hypothalamic dopamine in the regulation of prolactin secretion
Périodique
Hormone Research
Auteur(s)
Reymond  M. J., Porter  J. C.
ISSN
0301-0163
Statut éditorial
Publié
Date de publication
1985
Peer-reviewed
Oui
Volume
22
Numéro
3
Pages
142-52
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review
Résumé
The neuroendocrine control of prolactin (PRL) secretion is known to be a multifactorial process, but dopamine (DA) secreted by the tuberoinfundibular dopaminergic (TIDA) neurons of the hypothalamus is believed to exert a predominant inhibitory control on the secretion of PRL. The secretory activity of the TIDA neurons, including the rate of biosynthesis of DA and the rate of release of the neurohormone into hypophysial portal blood, can be readily evaluated in the rat. In most conditions in which an altered secretion of PRL has been documented, an altered secretory activity of the TIDA neurons has been found. When an acute reduction in the secretion of DA is observed, an increased secretion of PRL is associated, with an inverse relationship between DA and PRL concentrations in hypophysial portal and systemic blood, respectively. However, the secretion of PRL can be regulated by PRL itself through stimulation of the secretory activity of the TIDA neurons, and consequently hyperprolactinemia can be observed concomitantly with a sustained high secretion of DA, as seen after treatment with estrogen. The short loop feedback of PRL secretion seems to be impaired in the aging rat, since a sustained reduced hypothalamic secretion of DA is observed in spite of long-term hyperprolactinemia.
Mots-clé
Aging Animals Dopamine/*physiology/secretion Endorphins/pharmacology Estrogens/physiology Hydrazines/pharmacology Hypothalamus/drug effects/*physiology/secretion Methyltyrosines/pharmacology Morphine/pharmacology Neurons/physiology Prolactin/*secretion Rats Serotonin/pharmacology alpha-Methyltyrosine
Pubmed
Web of science
Création de la notice
11/02/2008 15:11
Dernière modification de la notice
20/08/2019 13:32
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