Heat Shock Protein 90 (Hsp90) in Fungal Growth and Pathogenesis

Détails

ID Serval
serval:BIB_0ACAE39A576A
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Heat Shock Protein 90 (Hsp90) in Fungal Growth and Pathogenesis
Périodique
Current Fungal Infection Reports
Auteur(s)
Lamoth  Frédéric, Juvvadi  Praveen R., Steinbach  William J.
ISSN
1936-3761 (Print)
1936-377X (Electronic)
Statut éditorial
Publié
Date de publication
2014
Volume
8
Numéro
4
Pages
296-301
Langue
anglais
Résumé
Invasive fungal infections, such as invasive candidiasis and invasive aspergillosis, have an important impact on morbidity and mortality in intensive care unit (ICU), cancer, and transplant patient populations. New therapies are required to overcome the limitations of the current antifungal armamentarium and the emergence of resistance. The heat shock protein 90 (Hsp90) is an essential molecular chaperone in eukaryotes that has engendered considerable interest as a potential target for novel cancer and antimicrobial therapies. Fungal Hsp90 was identified as a key regulator of antifungal resistance to both azole and echinocandin antifungals, with distinct features in the two major fungal pathogens, the yeast Candida albicans and the mold Aspergillus fumigatus. This review aims to provide a comprehensive summary on the role of Hsp90 in essential traits of fungal virulence, such as growth, development, stress adaptation and antifungal resistance, as well as the challenge of targeting this highly conserved protein to develop new antifungal strategies.
Mots-clé
Heat shock protein 90, Candida albicans, Aspergillus fumigatus, Invasive fungal infections, Antifungal resistance, Virulence, Calcineurin, Histone deacetylases, Caspofungin, Azoles
Création de la notice
12/10/2016 13:17
Dernière modification de la notice
20/08/2019 13:32
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