Role of melanopsin in circadian responses to light.

Détails

ID Serval
serval:BIB_0A9CD8A94247
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Role of melanopsin in circadian responses to light.
Périodique
Science
Auteur⸱e⸱s
Ruby N.F., Brennan T.J., Xie X., Cao V., Franken P., Heller H.C., O'Hara B.F.
ISSN
1095-9203[electronic], 0036-8075[linking]
Statut éditorial
Publié
Date de publication
2002
Peer-reviewed
Oui
Volume
298
Numéro
5601
Pages
2211-2213
Langue
anglais
Résumé
Melanopsin has been proposed as an important photoreceptive molecule for the mammalian circadian system. Its importance in this role was tested in melanopsin knockout mice. These mice entrained to a light/dark cycle, phase-shifted after a light pulse, and increased circadian period when light intensity increased. Induction of the immediate-early gene c-fos was observed after a nighttime light pulse in both wild-type and knockout mice. However, the magnitude of these behavioral responses in knockout mice was 40% lower than in wild-type mice. Although melanopsin is not essential for the circadian clock to receive photic input, it contributes significantly to the magnitude of photic responses.
Mots-clé
Animals, Biological Clocks/physiology, Circadian Rhythm/physiology, Darkness, Female, Gene Expression Regulation, Gene Targeting, Genes, fos, In Situ Hybridization, Light, Light Signal Transduction, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Motor Activity, Retinal Ganglion Cells/physiology, Rod Opsins/genetics, Rod Opsins/physiology, Suprachiasmatic Nucleus/physiology
Pubmed
Web of science
Création de la notice
24/01/2008 16:31
Dernière modification de la notice
20/08/2019 13:32
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