Native-like, long synthetic peptides as components of sub-unit vaccines: practical and theoretical considerations for their use in humans.

Détails

ID Serval
serval:BIB_0A3FA4743FE0
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Native-like, long synthetic peptides as components of sub-unit vaccines: practical and theoretical considerations for their use in humans.
Périodique
Molecular Immunology
Auteur(s)
Demotz S., Moulon C., Roggero M.A., Fasel N., Masina S.
ISSN
0161-5890 (Print)
ISSN-L
0161-5890
Statut éditorial
Publié
Date de publication
2001
Volume
38
Numéro
6
Pages
415-422
Langue
anglais
Résumé
Vaccines have been used as a successful tool in medicine by way of controlling many major diseases. In spite of this, vaccines today represent only a handful of all infectious diseases. Therefore, there is a pressing demand for improvements of existing vaccines with particular reference to higher efficacy and undisputed safety profiles. To this effect, as an alternative to available vaccine technologies, there has been a drive to develop vaccine candidate polypeptides by chemical synthesis. In our laboratory, we have recently developed a technology to manufacture long synthetic peptides of up to 130 residues, which are correctly folded and biologically active. This paper discusses the advantages of the molecularly defined, long synthetic peptide approach in the context of vaccine design, development and use in human vaccination.
Mots-clé
Drug Design, Humans, Peptides/chemical synthesis, Peptides/chemistry, Protein Folding, Vaccines, Subunit
Pubmed
Web of science
Création de la notice
24/01/2008 16:02
Dernière modification de la notice
20/08/2019 13:32
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