Background: Group B streptococcal early-onset sepsis (GBS EOS) inneonates has a mortality rate of similar to 5%, particularly in thepresence of multi-organ dysfunction. Fluid management is crucial inthese patients, and continuous venovenous haemofiltration (CVVH) shouldbe considered a therapeutic option even in newborn babies.Case report: After an uneventful pregnancy within hours after birth, afemale term infant presented with dyspnoea, irritability and cyanosis.The systemic inflammatory response syndrome (SIRS) progressed tomulti-organ dysfunction with acute respiratory distress syndrome(ARDS), impaired myocardial contractility, pulmonary hypertension andfluid overload. The maximum PRISM score was 51. The child requiredmaximal respiratory and inotropic support with high volume intravenousfluid administration. However, only by using of CVVH from day 5 to 14,we successfully resolved progressive pulmonary and cardiovasculardysfunction. The child improved directly after initiation of fluidremoval, was extubated on day 17 and discharged without obvioussequelae on day 57. All microbiology studies revealed GBS.Conclusion: Perinatal GBS-infections remain a major life-threateningevent for newborn babies. CVVH should be considered an option forreversing fluid overload even in neonates with overwhelming SIRS.Alternatively, extracorporeal membrane oxygenation (ECMO) is discussed.