Immunocytochemical localization of oestradiol and progesterone receptors in human endometrium: a tool to assess endometrial maturation
Détails
ID Serval
serval:BIB_0A2AFCFDF295
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Immunocytochemical localization of oestradiol and progesterone receptors in human endometrium: a tool to assess endometrial maturation
Périodique
Bailliere's Clinical Obstetrics and Gynaecology
ISSN
0950-3552
Statut éditorial
Publié
Date de publication
03/1991
Peer-reviewed
Oui
Volume
5
Numéro
1
Pages
107-15
Notes
Journal Article --- Old month value: Mar
Résumé
Uterine oestrogen (ER) and progesterone (PR) receptors are subject to fine hormonal control by oestradiol and progesterone. In order to assess the role of ER and PR measurement in the evaluation of endometrial maturation, both receptors were studied by immunocytochemical techniques using monoclonal antibodies during the menstrual cycle, and in women with inactive ovaries treated by different regimens of hormonal substitution with oestradiol and progesterone. During the normal menstrual cycle, the concentrations and distribution of ER and PR changed markedly. During the mid follicular period (days 7-8), a small proportion of stromal and glandular cells stained positively for PR while staining for ER was more intense and more frequent. During the late follicular phase and early luteal period (days 9-19), the staining for PR increased markedly in glandular cells. During the mid and late luteal phase (days 21-27), ER and PR staining disappeared in glandular cells. Thus, while oestradiol increases the staining for ER and PR in both glands and stroma, progesterone decreases ER and PR staining in the glands in a dramatic fashion. These variations, especially the disappearance of PR under the effect of progesterone, are potentially useful for studying the cumulative effect of progesterone on endometrial maturation. This was confirmed in anovulatory women, where a late luteal phase aspect was observed, i.e. the absence of a reduction in ER and PR in glandular cells. In women with ovarian failure, the disappearance of ER and PR in glandular cells is correlated with the duration of progesterone therapy.(ABSTRACT TRUNCATED AT 250 WORDS)
Mots-clé
Adolescent
Adult
Antibodies, Monoclonal
Arteries/chemistry
Endometrium/*chemistry/physiology
Female
Humans
Immunoenzyme Techniques
Luteal Phase/physiology
Menstrual Cycle/metabolism
Ovarian Diseases/drug therapy/metabolism
Receptors, Estradiol/*analysis
Receptors, Progesterone/*analysis
Uterus/blood supply
Pubmed
Web of science
Création de la notice
28/02/2008 11:37
Dernière modification de la notice
20/08/2019 12:32