Host-microorganism interactions in lung diseases.

Détails

ID Serval
serval:BIB_09FBBA51B73E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Host-microorganism interactions in lung diseases.
Périodique
Nature Reviews. Immunology
Auteur⸱e⸱s
Marsland B.J., Gollwitzer E.S.
ISSN
1474-1741 (Electronic)
ISSN-L
1474-1733
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
14
Numéro
12
Pages
827-835
Langue
anglais
Notes
Publication types: Journal Article
Résumé
Until recently, the airways were thought to be sterile unless infected; however, a shift towards molecular methods for the quantification and sequencing of bacterial DNA has revealed that the airways harbour a unique steady-state microbiota. This paradigm shift is changing the way that respiratory research is approached, with a clear need now to consider the effects of host-microorganism interactions in both healthy and diseased lungs. We propose that akin to recent discoveries in intestinal research, dysbiosis of the airway microbiota could underlie susceptibility to, and progression and chronicity of lung disease. In this Opinion article, we summarize current knowledge of the airway microbiota and outline how host-microorganism interactions in the lungs and other tissues might influence respiratory health and disease.
Pubmed
Web of science
Création de la notice
27/12/2014 10:20
Dernière modification de la notice
20/08/2019 13:32
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